Increasing the efficacy of immune checkpoint blockade therapy while mitigating toxicity is one of the major challenges in oncology research. In this issue of Cancer Cell, Hailemichael et al. provide a strong rationale for the combination of IL-6 blockade and dual inhibition of CTLA-4 and PD-1 to overcome this issue.

中文翻译：

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免疫检查点阻断治疗癌症患者的 IL-6 阻断：双赢策略

在减轻毒性的同时提高免疫检查点阻断疗法的功效是肿瘤学研究的主要挑战之一。在本期《癌细胞》中，Hailemichael 等人。为结合 IL-6 阻断和 CTLA-4 和 PD-1 双重抑制来克服这个问题提供了强有力的理由。