The global use of bisphenol S (BPS) has now been significantly increased for commensurate utilization as a substitute for BPA for its regulatory concerns. Though, previous reports indicated that BPS been also appeared as a toxic congener comparable to BPA. In the present study, we determined nephrotoxicity condition induced due to BPS exposure. Results indicated that BPS significantly promoted histopathological disturbance in the kidney, and altered the levels of biomarkers of kidney damage in serum and urine samples of Wistar rats. It is also indicated that BPS altered the expression of kidney damage biomarkers associated with glomerular and tubular injury. Additionally, we determined the perturbation of kidney metabolites in the underlying pathophysiological response of kidney injury due to BPS exposure. Gas chromatography–mass spectrometry based untargeted metabolomics exhibited 20 significantly perturbed metabolites. Moreover, metabolic pathway analysis revealed significant disturbance in the TCA cycle and pyruvate metabolism pathways.

由于监管问题，双酚 S (BPS) 的全球使用现已显着增加，以作为 BPA 的替代品。不过，之前的报告表明，BPS 也被视为与 BPA 相当的有毒同源物。在本研究中，我们确定了由于 BPS 暴露引起的肾毒性情况。结果表明，BPS 显着促进了肾脏的组织病理学紊乱，并改变了 Wistar 大鼠血清和尿液样本中肾脏损伤的生物标志物水平。还表明 BPS 改变了与肾小球和肾小管损伤相关的肾损伤生物标志物的表达。此外，我们确定了由于 BPS 暴露导致肾损伤的潜在病理生理反应中肾脏代谢物的扰动。基于气相色谱-质谱的非靶向代谢组学显示出 20 种显着扰动的代谢物。此外，代谢途径分析揭示了 TCA 循环和丙酮酸代谢途径的显着干扰。