Poly ε-caprolactone (PCL) synthesized by ring-opening polymerization method, and then it blended with polylactic acid (PLA). The blend was loaded with Cucurbita moschata leaf extract. The prepared PCL/PLA blend loaded with C. moschata was characterized with ATR-IR, TGA, and DSC; also the surface morphology was examined with an optical microscope. The thermal analysis results showed that the plant extract reduces the thermal stability and melting temperatures of the pure polymer blends. Optical microscope images showed that the plant extract filled the spaces between the polymer molecules. The antimicrobial effects of the pure polymer blend, pure plant leaf extract, and plant-loaded polymer blend against Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Bacillus megaterium, and Candida albicans microorganisms were examined, and it was observed that the antimicrobial effects increase with increasing concentration. Finally, the cytotoxic activities of the samples on the human breast cancer (MDA-MB-231) cell line were performed by the MTT analysis method. While the C. moschata leaf extract and polymer blend showed cytotoxic effect, the cytotoxic effect of the polymer blend loaded with plant extract was quite low.

采用开环聚合法合成聚ε-己内酯（PCL），再与聚乳酸（PLA）共混。混合物中装有南瓜叶提取物。用 ATR-IR、TGA 和 DSC对制备的负载C. moschata的 PCL/PLA 共混物进行了表征；还用光学显微镜检查了表面形态。热分析结果表明，植物提取物降低了纯聚合物共混物的热稳定性和熔融温度。光学显微镜图像显示植物提取物填充了聚合物分子之间的空间。纯聚合物混合物、纯植物叶提取物和植物负载聚合物混合物对金黄色葡萄球菌的抗菌作用，检测了肺炎克雷伯菌、大肠埃希菌、巨大芽孢杆菌和白色念珠菌微生物，观察到抗菌作用随着浓度的增加而增加。最后，通过MTT分析方法进行样品对人乳腺癌（MDA-MB-231）细胞系的细胞毒活性。虽然C. moschata叶提取物和聚合物混合物显示出细胞毒性作用，但负载植物提取物的聚合物混合物的细胞毒性作用非常低。