We discuss how metabolism changes during different phases of the cell cycle to sustain biosynthesis and replication in normal and cancer cells. We also highlight how several master regulators of cell cycle, such as cyclin–cyclin-dependent kinases (cyc–CDK complexes) and E3 proteasome ligases, modulate key metabolic enzymes to support cell-cycle progression.

中文翻译：

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细胞周期进程中的代谢振荡

我们讨论了细胞周期不同阶段的代谢如何变化，以维持正常细胞和癌细胞的生物合成和复制。我们还强调了细胞周期的几种主要调节因子，例如细胞周期蛋白-细胞周期蛋白依赖性激酶（cyc-CDK 复合物）和 E3 蛋白酶体连接酶，如何调节关键代谢酶以支持细胞周期进程。