Fiber Optic Plasmonic Sensors Based on Nanodome Arrays with Nanogaps,ACS Sensors

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Fiber Optic Plasmonic Sensors Based on Nanodome Arrays with Nanogaps
ACS Sensors ( IF 8.2 ) Pub Date : 2022-05-06 , DOI: 10.1021/acssensors.2c00154
Hyeong-Min Kim ₁ , Ho-Young Lee ₂ , Jae-Hyoung Park ₁ , Seung-Ki Lee ₁

Affiliation

In this study, a high-performance fiber optic surface plasmon resonance (FO-SPR) sensor using a dome array with nanogaps (DANG) is proposed for label-free real-time detection of biomolecules. A novel and simple method using polymer beads enables high sensitivity by allowing hotspots with nanometer spacing between the Au dome and the surrounding film. The nanodome structure, which comprises a polymer core and a Au shell, induces a localized surface plasmon, expands the sensing area, and extensively enhances the electromagnetic field. The refractive index sensitivity of the FO-SPR sensor with nanostructures, i.e., with nanogaps and nanodomes, was found to be 7.8 times higher than that of the FO-SPR sensor without nanostructures. The proposed sensor achieved a low detection limit of 38 fg/mL while quantifying thyroglobulin antibody–antigen interactions and exhibited excellent selectivity. In addition, it helped detect serum samples with a 103% recovery rate.

中文翻译：

基于具有纳米间隙的纳米圆顶阵列的光纤等离子体传感器

在这项研究中，提出了一种使用具有纳米间隙 (DANG) 的圆顶阵列的高性能光纤表面等离子体共振 (FO-SPR) 传感器，用于生物分子的无标记实时检测。一种使用聚合物珠的新颖而简单的方法通过允许在 Au 圆顶和周围薄膜之间具有纳米间距的热点来实现高灵敏度。由聚合物核和金壳组成的纳米圆顶结构可诱导局部表面等离激元，扩大传感区域，并广泛增强电磁场。发现具有纳米结构（即具有纳米间隙和纳米圆顶）的 FO-SPR 传感器的折射率灵敏度比没有纳米结构的 FO-SPR 传感器高 7.8 倍。所提出的传感器在量化甲状腺球蛋白抗体-抗原相互作用的同时实现了 38 fg/mL 的低检测限，并表现出出色的选择性。此外，它还以 103% 的回收率帮助检测血清样本。

更新日期：2022-05-06

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