Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets,Alzheimer's & Dementia

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Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2022-05-01 , DOI: 10.1002/alz.12686
Jairo Ramos ₁ , Laura J Caywood ₁ , Michael B Prough ₁ , Jason E Clouse ₁ , Sharlene D Herington ₁ , Susan H Slifer ₁ , M Denise Fuzzell ₂ , Sarada L Fuzzell ₂ , Sherri D Hochstetler ₂ , Kristy L Miskimen ₂ , Leighanne R Main ₂ , Michael D Osterman _{2,

3} , Andrew F Zaman ₁ , Patrice L Whitehead ₁ , Larry D Adams ₁ , Renee A Laux ₂ , Yeunjoo E Song ₂ , Tatiana M Foroud ₄ , Richard P Mayeux _{5,

6,

7} , Peter St George-Hyslop ₈ , Paula K Ogrocki ₉ , Alan J Lerner ₉ , Jeffery M Vance _{1,

10} , Michael L Cuccaro _{1,

10} , Jonathan L Haines _{2,

3} , Margaret A Pericak-Vance _{1,

10} , William K Scott _{1,

10}

Affiliation

John P. Hussman Institute for Human Genomics, University of Miami Miller School, of Medicine, Miami, Florida, USA.
Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA.
Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA.
Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA.
Department of Neurology, Columbia University, New York, New York, USA.
University of Toronto, Toronto, Ontario, Canada.
University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
The Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.

Studies of cognitive impairment (CI) in Amish communities have identified sibships containing CI and cognitively unimpaired (CU) individuals. We hypothesize that CU individuals may carry protective alleles delaying age at onset (AAO) of CI.

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