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One enzyme, many substrates: How the vaccinia virus enzyme D9 decaps host and viral mRNAs alike
Structure ( IF 4.4 ) Pub Date : 2022-05-05 , DOI: 10.1016/j.str.2022.04.008
Vincent D Maciej 1 , Sutapa Chakrabarti 1
Affiliation  

The decapping enzyme D9 acts on host mRNA and viral double-stranded RNA to promote viral replication in host cells. In this issue of Structure, Peters et al. (2022) present crystal structures of m7GDP-bound D9 to highlight how a conventional fold is adapted to target a wide variety of RNA substrates.



中文翻译:

一种酶,多种底物:牛痘病毒酶 D9 如何对宿主和病毒 mRNA 进行脱壳

脱帽酶 D9 作用于宿主 mRNA 和病毒双链 RNA,以促进病毒在宿主细胞中的复制。在本期结构中,彼得斯等人。(2022) 展示了 m 7 GDP 结合的 D9的晶体结构,以突出传统折叠如何适应于靶向多种 RNA 底物。

更新日期:2022-05-06
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