Even though amoxicillin is used as an antibacterial drug in some foods such as fish, chick, etc. However, the use of amoxicillin in the food industry is prohibited. Therefore, rapid detection and sensitive detection at ultra-low concentration of amoxicillin is very important for human. Surface enhanced Raman scattering (SERS) is fast and reliable method to determine the molecules at ultra-low concentration. In this study, silver nanocubes were synthesized and used as SERS active substrate. The synthesized Ag NCs exhibit an excellent sensitivity towards the detection of amoxicillin at the lowest concentration of 10⁻⁹ M based on the effect resulting from Ag NCs leading to the high electromagnetic effect and chemical mechanism. The dynamic linear regression between the Raman intensity and amoxicillin concentration over seven orders of magnitude (from 10⁻⁴ to 10⁻⁹ M) was excellent with high reliability (R² = 0.99). On the one hand, SERS substrate can be used after storing for 20 days. Because Ag NCs also demonstrated remarkable recyclability, reproducibility, and chemical stability. As a result, Ag NCs can be used as a potential SERS substrate to detect amoxicillin at ultra-low concentration.

尽管阿莫西林在一些食品如鱼、鸡等中用作抗菌药物。但是，在食品工业中使用阿莫西林是被禁止的。因此，超低浓度阿莫西林的快速检测和灵敏检测对人类非常重要。表面增强拉曼散射 (SERS) 是确定超低浓度分子的快速可靠的方法。在这项研究中，合成了银纳米立方体并用作 SERS 活性基底。合成的 Ag NC 对检测最低浓度 10 ^{-9的阿莫西林表现出极好的灵敏度}M 基于 Ag NCs 产生的影响，导致高电磁效应和化学机制。拉曼强度和阿莫西林浓度之间的动态线性回归超过七个数量级（从 10 ^-4到 10 ^-9 M），可靠性高（R ²  = 0.99）。一方面，SERS基底可以在储存20天后使用。因为 Ag NCs 还表现出显着的可回收性、再现性和化学稳定性。因此，Ag NCs 可用作潜在的 SERS 底物，以检测超低浓度的阿莫西林。