Coleus forskohlii Briq. is an important medicinal herb, endowed with a wide range of medicinal properties against the variety of ailments. Seven germplasm of C. forskohlii collected from different phyto-geographical locations and identification of elite chemotype was performed with the help of high performance thin layer chromatography. Data of soil analysis correlated with the bioactive compounds and inhibitory potential of the species. Quantification of forskolin and its isomer (iso-forskolin) content were done in all the collected samples of C. forskohlii, which revealed a wide range of variations, varying from 1.15–0.004% and 0.0091 to 0.1077% per dry weights basic, respectively. Variation in the bioactive content may be due to the soil nature and environmental factors. Soil analysis of collected samples demonstrated that there is significant variation in available NPK and micronutrient content and may be reasoned for existing chemotypic variability. In vitro biological activity (antioxidant and antidiabetic) analyses were performed, which reveals that germplasms have a high amount of forskolin and iso-forskolin, both show more activity. The aim of this study was to elucidate the effect of elicitors and precursors on the production of bioactive compounds and identification of best elite germplasm among the populations, to provide basic lead to the industry for commercial exploitability including its location-specific commercial cultivation.

中文翻译：

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Coleus forskohlii Briq. 的化学型变异性研究，从印度不同植物地理区域采集的样品及其抑制潜力的评估

锦紫苏 forskohlii Briq。是一种重要的草药，具有广泛的药用特性，可治疗多种疾病。在高效薄层色谱的帮助下，从不同的植物地理位置收集了七种毛喉毛喉植物的种质资源，并进行了优良化学型的鉴定。土壤分析数据与该物种的生物活性化合物和抑制潜力相关。在所有收集的毛喉毛喉素样品中对毛喉素及其异构体（异毛喉素）含量进行了定量，结果显示变化范围很广，分别为每单位干重基础的 1.15-0.004% 和 0.0091-0.1077%。生物活性含量的变化可能是由于土壤性质和环境因素造成的。对收集的样本进行的土壤分析表明，可用的 NPK 和微量营养素含量存在显着差异，并且可能是现有化学型变异性的原因。进行了体外生物活性（抗氧化和抗糖尿病）分析，结果表明种质中含有大量的毛喉素和异毛喉素，两者都表现出更高的活性。本研究的目的是阐明诱导子和前体对生物活性化合物生产的影响以及种群中最佳优良种质的鉴定，为该行业的商业开发提供基本线索，包括其特定地点的商业种植。进行了体外生物活性（抗氧化和抗糖尿病）分析，结果表明种质中含有大量的毛喉素和异毛喉素，两者都表现出更高的活性。本研究的目的是阐明诱导子和前体对生物活性化合物生产的影响以及种群中最佳优良种质的鉴定，为该行业的商业开发提供基本线索，包括其特定地点的商业种植。进行了体外生物活性（抗氧化和抗糖尿病）分析，结果表明种质中含有大量的毛喉素和异毛喉素，两者都表现出更高的活性。本研究的目的是阐明诱导子和前体对生物活性化合物生产的影响以及种群中最佳优良种质的鉴定，为该行业的商业开发提供基本线索，包括其特定地点的商业种植。