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Computed Origami Tomography
SIAM Review ( IF 10.8 ) Pub Date : 2022-05-05 , DOI: 10.1137/20m1378247
Axel Kittenberger , Leonidas Mindrinos , Otmar Scherzer

SIAM Review, Volume 64, Issue 2, Page 469-484, May 2022.
In this paper, we provide assembly instructions for an easy-to-build experimental setup in order to gain practical experience with tomography. As such, this paper can be seen as a complementary work to excellent undergraduate-level mathematical textbooks concerned with the basic mathematical principles of tomography. Since the setup uses light for tomographic imaging, the objects investigated need to be light transparent, such as origami figures. Should the reader want to experiment with computational tomographic reconstructions without assembling the device, we provide a database of several objects together with their tomographic measurements and publicly available software. Moreover, recent advances in cryo-imaging have enabled three-dimensional high-resolution visualization of single particles such as, for instance, viruses. To exemplify, and demonstrate, single particle cryo-electron microscopy, we provide an advanced assembly that we use to generate data simulating a cryo-recording. We also discuss some of the major practical difficulties in reconstructing particles from cryo-microscopic data.


中文翻译:

计算机折纸断层扫描

SIAM 评论,第 64 卷,第 2 期,第 469-484 页,2022 年 5 月。
在本文中,我们为易于构建的实验设置提供了组装说明,以便获得断层扫描的实践经验。因此,本文可以看作是对有关断层扫描基本数学原理的优秀本科数学教科书的补充。由于该设置使用光进行断层成像,因此所研究的对象需要是透光的,例如折纸人物。如果读者想在不组装设备的情况下尝试计算断层重建,我们提供了一个包含多个对象的数据库以及它们的断层测量和公开可用的软件。此外,冷冻成像技术的最新进展使单个粒子(例如病毒)的三维高分辨率可视化成为可能。举例来说,并演示单粒子低温电子显微镜,我们提供了一个先进的组件,用于生成模拟低温记录的数据。我们还讨论了从低温显微镜数据重建粒子的一些主要实际困难。
更新日期:2022-05-06
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