Intracellular bacteria have developed a multitude of mechanisms to influence the post-translational modifications (PTMs) of host proteins to pathogen advantages. The recent explosion of insights into the diversity and sophistication of host PTMs and their manipulation by infectious agents challenges us to formulate a comprehensive vision of this complex and dynamic facet of the host-pathogen interaction landscape. As new discoveries continue to shed light on the central roles of PTMs in infectious diseases, technological advances foster our capacity to detect old and new PTMs and investigate their control and impact during pathogenesis, opening new possibilities for chemical intervention and infection treatment. Here, we present a comprehensive overview of these pathogenic mechanisms and offer perspectives on how these insights may contribute to the development of a new class of therapeutics that are urgently needed to face rising antibiotic resistances.

细胞内细菌已开发出多种机制来影响宿主蛋白的翻译后修饰 (PTM) 以发挥病原体优势。最近对宿主 PTM 的多样性和复杂性以及感染因子操纵的见解爆炸式增长，挑战我们对宿主 - 病原体相互作用景观的这一复杂和动态方面形成一个全面的看法。随着新发现继续揭示 PTM 在传染病中的核心作用，技术进步增强了我们检测新旧 PTM 并研究其在发病机制中的控制和影响的能力，为化学干预和感染治疗开辟了新的可能性。这里，