CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression.

中文翻译：

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circRNA/Wnt 轴在癌症中的功能作用

环状RNA是共价闭合的非编码RNA，广泛表达于从病毒到植物再到哺乳动物的多种物种中。CircRNA 在 Wnt 通路中富集。异常 Wnt 通路激活涉及各种类型癌症的发展。越来越多的证据表明，circRNA/Wnt 轴调节癌症相关基因的表达，然后调节癌症进展。Wnt通路相关的circRNA表达明显与许多临床特征相关。CircRNAs 可以通过与 Wnt 通路相互作用来调节细胞生物学功能。此外，Wnt 通路相关的 circRNA 是癌症诊断、预后评估和治疗的有希望的潜在生物标志物。在我们的评论中，