Site-Specific Controlled-Release Imidazolate Framework-8 for Dazomet Smart Delivery to Improve the Effective Utilization Rate and Reduce Biotoxicity,Journal of Agricultural and Food Chemistry

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Site-Specific Controlled-Release Imidazolate Framework-8 for Dazomet Smart Delivery to Improve the Effective Utilization Rate and Reduce Biotoxicity
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-05-04 , DOI: 10.1021/acs.jafc.2c00353
Lirui Ren ₁ , Jianing Zhao ₂ , Wenjing Li ₁ , Qingjie Li ₁ , Daqi Zhang ₁ , Wensheng Fang ₁ , Dongdong Yan ₁ , Yuan Li ₁ , Qiuxia Wang ₁ , Xi Jin ₃ , Aocheng Cao _{1,

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Affiliation

An accurate controlled-release strategy of pesticides is considered desirable in sustainable agriculture. A site-specific nanorelease system of dazomet (DZ) was proposed by employing the zeolitic imidazolate framework-8 composite (DZ@ZIF-8) by a one-pot method. The synthetic parameters of DZ@ZIF-8 were optimized, and the loading content of DZ was maximized. ZIF-8 endowed DZ with a pH-sensitive behavior. The collapse of the DZ@ZIF-8 structure and the site-specific release of DZ were triggered by acidic substances produced by Botrytis cinerea. In vitro and pot experiments showed that the fungicidal activity of DZ@ZIF-8 was about 36.3 and 42.7% higher than that of DZ, respectively. DZ is conventionally used before a crop is planted because of its volatility and toxicity. However, DZ@ZIF-8 could avoid phytotoxicity of DZ to plants, which made the application of DZ possible during plant growth. Moreover, the acute toxicity to zebrafish changed from high to moderate levels. This study highlights a potential strategy that improves DZ effective utilization and reduces side effects.

中文翻译：

用于 Dazomet 智能递送的特定位点控释咪唑酯 Framework-8，以提高有效利用率并降低生物毒性

在可持续农业中，准确的农药控释策略被认为是可取的。采用一锅法，采用沸石咪唑酯骨架-8复合材料（DZ@ZIF-8），提出了一种特定位点的dazomet（DZ）纳米释放系统。优化了DZ@ZIF-8的合成参数，使DZ的负载量最大化。ZIF-8 赋予 DZ 对 pH 值敏感的行为。DZ@ZIF-8 结构的坍塌和 DZ 的位点特异性释放是由灰霉病菌产生的酸性物质引发的。体外和盆栽实验表明，DZ@ZIF-8的杀菌活性分别比DZ高36.3%和42.7%。由于 DZ 的挥发性和毒性，通常在种植作物之前使用 DZ。而DZ@ZIF-8可以避免DZ对植物的药害，这使得DZ在植物生长过程中的应用成为可能。此外，对斑马鱼的急性毒性从高水平变为中等水平。这项研究强调了一种潜在的策略，可以提高 DZ 的有效利用率并减少副作用。

更新日期：2022-05-04

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