Ketones as strategic building blocks for the synthesis of natural product-inspired compounds,Chemical Society Reviews

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Ketones as strategic building blocks for the synthesis of natural product-inspired compounds
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2022-05-04 , DOI: 10.1039/d2cs00101b
Daniel J Foley _{1,

2} , Herbert Waldmann _{2,

3}

Affiliation

Natural product-inspired compound collections serve as excellent sources for the identification of new bioactive compounds to treat disease. However, such compounds must necessarily be more structurally-enriched than traditional screening compounds, therefore inventive synthetic strategies and reliable methods are needed to prepare them. Amongst the various possible starting materials that could be considered for the synthesis of natural product-inspired compounds, ketones can be especially valuable due to the vast variety of complexity-building synthetic transformations that they can take part in, their high prevalence as commercial building blocks, and relative ease of synthesis. With a view towards developing a unified synthetic strategy for the preparation of next generation bioactive compound collections, this review considers whether ketones could serve as general precursors in this regard, and summarises the opulence of synthetic transformations available for the annulation of natural product ring-systems to ketone starting materials.

中文翻译：

酮作为合成受天然产物启发的化合物的战略组成部分

受天然产物启发的化合物集合是鉴定治疗疾病的新生物活性化合物的极好来源。然而，这些化合物必须比传统的筛选化合物结构更丰富，因此需要创造性的合成策略和可靠的方法来制备它们。在可以考虑用于合成受天然产物启发的化合物的各种可能的起始材料中，酮可能特别有价值，因为它们可以参与各种各样的复杂性合成转化，它们作为商业构件的普遍性很高，并且相对容易合成。为了制定统一的合成策略来制备下一代生物活性化合物集合，

更新日期：2022-05-04

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