Fundamentals, biomedical applications and future potential of micro-scale cavitation-a review,Lab on a Chip

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Fundamentals, biomedical applications and future potential of micro-scale cavitation-a review
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-05-02 , DOI: 10.1039/d2lc00169a
Seyedali Seyedmirzaei Sarraf _{1,

2} , Farzad Rokhsar Talabazar _{1,

2} , Ilayda Namli _{1,

2} , Mohammadamin Maleki _{1,

2} , Araz Sheibani Aghdam _{1,

2} , Ghazaleh Gharib _{1,

2,

3} , Dmitry Grishenkov ₄ , Morteza Ghorbani _{1,

2,

3} , Ali Koşar _{1,

2,

3}

Affiliation

Thanks to the developments in the area of microfluidics, the cavitation-on-a-chip concept enabled researchers to control and closely monitor the cavitation phenomenon in micro-scale. In contrast to conventional scale, where cavitation bubbles are hard to be steered and manipulated, lab-on-a-chip devices provide suitable platforms to conduct smart experiments and design reliable devices to carefully harness the collapse energy of cavitation bubbles in different bio-related and industrial applications. However, bubble behavior deviates to some extent when confined to micro-scale geometries in comparison to macro-scale. Therefore, fundamentals of micro-scale cavitation deserve in-depth investigations. In this review, first we discussed the physics and fundamentals of cavitation induced by tension-based as well as energy deposition-based methods within microfluidic devices and discussed the similarities and differences in micro and macro-scale cavitation. We then covered and discussed recent developments in bio-related applications of micro-scale cavitation chips. Lastly, current challenges and future research directions towards the implementation of micro-scale cavitation phenomenon to emerging applications are presented.

中文翻译：

微尺度空化的基础、生物医学应用和未来潜力——综述

由于微流体领域的发展，芯片上的空化概念使研究人员能够控制和密切监测微尺度的空化现象。与空化气泡难以控制和操纵的传统规模相比，芯片实验室设备提供了合适的平台来进行智能实验并设计可靠的设备来仔细利用不同生物相关领域中空化气泡的坍塌能量和工业应用。然而，与宏观尺度相比，当局限于微观尺度几何时，气泡行为在一定程度上有所偏差。因此，微尺度空化的基本原理值得深入研究。在本次审查中，首先，我们讨论了微流体装置中基于张力和基于能量沉积的方法引起的空化的物理学和基本原理，并讨论了微观和宏观空化的异同。然后，我们介绍并讨论了微型空化芯片的生物相关应用的最新发展。最后，提出了将微尺度空化现象应用于新兴应用的当前挑战和未来研究方向。

更新日期：2022-05-02

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