Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway signals by a non-canonical mechanism to control protein translation through the unfolded protein response sensor PERK, and thereby contributes to cellular senescence and organ fibrosis.

中文翻译：

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带有 PERKy 轨迹的精选 STING

cGAS-STING 通路的细胞溶质 DNA 传感对于维持先天免疫防御程序至关重要。一项新的研究表明，cGAS-STING 通路通过非典型机制发出信号，通过未折叠的蛋白质反应传感器 PERK 控制蛋白质翻译，从而促进细胞衰老和器官纤维化。