Introduction: Diabetes mellitus (DM) is a risk factor for Alzheimer’s disease (AD). It has also been pointed out that AD associated with DM may have unique characteristics. However, the characteristics of impairment in daily functioning when associated with DM have not been sufficiently investigated. Methods: In the present study, we compared the characteristics of 261 patients with AD diagnosed in the outpatient memory clinic of a university hospital, divided into diabetic and nondiabetic groups. The MMSE was used to assess cognitive function, and the Dementia Assessment Sheet for Community-based Integrated Care System 21-items (DASC-21) was used as an observational method to assess cognitive function and activities of daily livings. The two groups were compared. Furthermore, simple and multiple regression analysis was carried out in order to find the independent association of age, sex, education, DM, and HbA1c with the DASC-21 and each individual item of the DASC-21. Results: Diabetic subjects were as follows: MMSE 18.8 ± 4.0, DASC-21 46.0 ± 13.2, and HbA1c 7.07 ± 1.24%, respectively. On the other hand, nondiabetic subjects were as follows: MMSE 19.0 ± 4.5 and DASC-21 42.1 ± 12.2, respectively. In the diabetic group, total score of DASC-21 was higher (DM vs. nondiabetes mellitus [NDM]: 46.0 ± 13.2 vs. 42.1 ± 12.2; p #x3c; 0.05) and solving issues and common sense on the DASC-21 were higher than in the nondiabetic group (NDM) (DM vs. NDM: 8.58 ± 2.71 vs. 7.76 ± 2.66; p #x3c; 0.05). Multiple regression analysis showed that the presence of DM was the significant determinant of solving issues and common sense on the DASC-21 (p #x3c; 0.05). Conclusions: In AD patients, DM may be associated with impairment of solving issues and common sense.
Dement Geriatr Cogn Disord Extra 2022;12:76–81

中文翻译：

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DASC-21 评估的糖尿病对阿尔茨海默病患者日常功能和认知的影响

简介：糖尿病（DM）是阿尔茨海默病（AD）的危险因素。也有人指出，与 DM 相关的 AD 可能具有独特的特征。然而，与 DM 相关的日常功能障碍的特征尚未得到充分研究。方法：在本研究中，我们比较了在一所大学医院门诊记忆门诊诊断出的 261 名 AD 患者的特征，分为糖尿病组和非糖尿病组。MMSE 用于评估认知功能，社区综合护理系统 21 项痴呆评估表 (DASC-21) 用作评估认知功能和日常生活活动的观察方法。对两组进行了比较。此外，进行了简单和多元回归分析，以发现年龄、性别、教育、DM 和 HbA1c 与 DASC-21 和 DASC-21 的每个单独项目的独立关联。结果：糖尿病受试者如下：MMSE 18.8 ± 4.0、DASC-21 46.0 ± 13.2 和 HbA1c 分别为 7.07 ± 1.24%。另一方面，非糖尿病受试者如下：MMSE 19.0 ± 4.5 和 DASC-21 42.1 ± 12.2，分别。在糖尿病组中，DASC-21 的总分较高（DM 与非糖尿病 [NDM]：46.0​​ ± 13.2 vs. 42.1 ± 12.2；p #x3c；0.05）并且解决问题和 DASC-21 的常识是高于非糖尿病组 (NDM) (DM vs. NDM: 8.58 ± 2.71 vs. 7.76 ± 2.66; p #x3c; 0.05)。多元回归分析表明，DM 的存在是 DASC-21 上解决问题和常识的重要决定因素 ( p #x3c; 0.05)。结论：在 AD 患者中，DM 可能与解决问题和常识的障碍有关。
Dement Geriatr Cogn Disord Extra 2022；12：76–81