Genetic associations with healthy ageing among Chinese adults,npj Aging

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Genetic associations with healthy ageing among Chinese adults
npj Aging ( IF 4.1 ) Pub Date : 2022-05-02 , DOI: 10.1038/s41514-022-00086-x
Xuling Chang _{1,

2} , Yan-Feng Zhou ₃ , Ling Wang ₄ , Jianjun Liu _{4,

5} , Jian-Min Yuan _{6,

7} , Chiea-Chuen Khor _{4,

8} , Chew-Kiat Heng _{1,

2} , An Pan _{3,

9,

10} , Woon-Puay Koh _{11,

12} , Rajkumar Dorajoo _{4,

13}

Affiliation

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.
Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, 119074, Singapore.
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15232, USA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.
Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117545, Singapore.
Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, 117609, Singapore.
Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.

The genetic basis of overall healthy ageing, especially among the East-Asian population is understudied. We conducted a genome-wide association study among 1618 Singapore Chinese elderly participants (65 years or older) ascertained to have aged healthily and compared their genome-wide genotypes to 6221 participants who did not age healthily, after a 20-year follow-up. Two genetic variants were identified (P_Meta < 2.59 × 10⁻⁸) to be associated with healthy aging, including the LRP1B locus previously associated in long-lived individuals without cognitive decline. Our study sheds additional insights on the genetic basis of healthy ageing.

更新日期：2022-05-02

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