Preclinical studies have revealed that the elevation of nicotinamide adenine dinucleotide (NAD + ) upon the administration of nicotinamide mononucleotide (NMN), an NAD + precursor, can mitigate aging-related disorders; however, human data on this are limited. We investigated whether the chronic oral supplementation of NMN can elevate blood NAD + levels and alter physiological dysfunctions in healthy older participants. We administered 250 mg NMN per day to aged men for 6 or 12 weeks in a placebo-controlled, randomized, double-blind, parallel-group trial. Chronic NMN supplementation was well tolerated and caused no significant deleterious effect. Metabolomic analysis of whole blood samples demonstrated that oral NMN supplementation significantly increased the NAD + and NAD + metabolite concentrations. There were nominally significant improvements in gait speed and performance in the left grip test, which should be validated in larger studies; however, NMN exerted no significant effect on body composition. Therefore, chronic oral NMN supplementation can be an efficient NAD + booster for preventing aging-related muscle dysfunctions in humans.

临床前研究表明，在施用 NAD + 前体烟酰胺单核苷酸 (NMN) 后，烟酰胺腺嘌呤二核苷酸 (NAD + ) 的升高可以减轻与衰老相关的疾病；然而，这方面的人类数据是有限的。我们研究了长期口服 NMN 是否可以提高健康老年参与者的血液 NAD + 水平并改变生理功能障碍。在安慰剂对照、随机、双盲、平行组试验中，我们每天给老年男性服用 250 mg NMN，持续 6 或 12 周。长期补充 NMN 具有良好的耐受性，并且没有造成明显的有害影响。全血样本的代谢组学分析表明，口服 NMN 补充剂显着增加了 NAD + 和 NAD + 代谢物浓度。在左握力测试中，步态速度和表现名义上有显着改善，这应该在更大的研究中得到验证；然而，NMN 对身体成分没有显着影响。因此，长期口服 NMN 补充剂可以成为有效的 NAD + 助推器，用于预防人类与衰老相关的肌肉功能障碍。