Diet, Trimethylamine Metabolism, and Mitochondrial DNA: An Observational Study,Molecular Nutrition & Food Research

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Diet, Trimethylamine Metabolism, and Mitochondrial DNA: An Observational Study
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-05-01 , DOI: 10.1002/mnfr.202200003
Laura Bordoni ₁ , Anna M Malinowska ₂ , Irene Petracci ₃ , Artur Szwengiel ₄ , Rosita Gabbianelli ₁ , Agata Chmurzynska ₂

Affiliation

Mitochondrial DNA copy number (mtDNAcn) and its methylation level in the D-loop area have been correlated with metabolic health and are suggested to vary in response to environmental stimuli, including diet. Circulating levels of trimethylamine-n-oxide (TMAO), which is an oxidative derivative of the trimethylamine (TMA) produced by the gut microbiome from dietary precursors, have been associated with chronic diseases and are suggested to have an impact on mitochondrial dynamics. This study is aimed to investigate the relationship between diet, TMA, TMAO, and mtDNAcn, as well as DNA methylation.

中文翻译：

饮食、三甲胺代谢和线粒体 DNA：一项观察性研究

线粒体 DNA 拷贝数 (mtDNAcn) 及其在 D 环区域的甲基化水平与代谢健康相关，并被认为会随着环境刺激（包括饮食）而变化。三甲胺-n-氧化物 (TMAO) 的循环水平是由膳食前体的肠道微生物组产生的三甲胺 (TMA) 的氧化衍生物，它与慢性疾病有关，并被认为对线粒体动力学有影响。本研究旨在调查饮食、TMA、TMAO 和 mtDNAcn 以及 DNA 甲基化之间的关系。

更新日期：2022-05-01

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