The incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of the Hsp family. It has attracted particular attention in CRC pathogenesis since it is involved in fundamental cell functions for cell survival. Evidence shows that Hsp27 plays important role in CRC progression and metastasis. Hsp27 overexpression has been observed in CRC and is suggested to be associated with CRC's poor prognosis. In the present review, we focus on the current knowledge of the role of Hsp27 in CRC carcinogenesis and the underlying mechanisms. In addition, we discuss the value of targeting Hsp27 in CRC treatment.

中文翻译：

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热休克蛋白 27 在结直肠癌的发生和治疗中的作用。

近几十年来，结直肠癌 (CRC) 的发病率显着增加，这使该疾病成为一个重要的全球健康问题。尽管做出了许多努力，但对于 CRC 没有有用的预后或诊断生物标志物。热休克蛋白 27 (Hsp27) 是 Hsp 家族中研究最多的成员之一。它在 CRC 发病机制中引起了特别的关注，因为它涉及细胞存活的基本细胞功能。证据表明 Hsp27 在 CRC 进展和转移中起重要作用。已在 CRC 中观察到 Hsp27 过表达，并被认为与 CRC 的不良预后有关。在本综述中，我们重点关注 Hsp27 在 CRC 致癌作用和潜在机制中的作用的当前知识。此外，我们还讨论了靶向 Hsp27 在 CRC 治疗中的价值。