Tissue Engineering for the Diaphragm and its Various Therapeutic Possibilities – A Systematic Review,Advanced Therapeutics

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Tissue Engineering for the Diaphragm and its Various Therapeutic Possibilities – A Systematic Review
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2022-04-04 , DOI: 10.1002/adtp.202100247
Agnes K Boehm ₁ , Karl H Hillebrandt _{1,

2} , Tomasz Dziodzio _{1,

2} , Felix Krenzien _{1,

2} , Jens Neudecker ₁ , Simone Spuler ₃ , Johann Pratschke _{1,

4} , Igor M Sauer _{1,

4} , Marco N Andreas ₁

Affiliation

Diaphragmatic impairments exhibit high morbidity as well as mortality while current treatment options remain unsatisfactory. Tissue engineering (TE) approaches have explored the generation of an optimal biocompatible scaffold for diaphragmatic repair through tissue decellularization or de novo construction, with or without the addition of cells. The authors conducted a systematic review on the current state of the art in diaphragmatic tissue engineering (DTE) and found 24 articles eligible for final synthesis. The included approaches studied decellularization-based graft generation (9) and de novo bioscaffold construction (9). Three studies focused on in vitro host-scaffold interaction with synthesized, recellularized grafts (2) and decellularized extracellular matrix scaffolds (1). Another three studies investigated evaluation tools for decellularization efficacy. Among all studies, recellularization is performed in both decellularization-based (4) and de novo generated scaffolds (4). De novo constructed biocomposites as well as decellularized and recellularized scaffolds induced pro-regenerative remodeling and recovery of diaphragmatic function in all examined animal models. Potential therapeutic applications comprise substance defects requiring patch repair, such as congenital diaphragmatic hernia, and functional diseases demanding an entire organ transplant, like muscular dystrophies or dysfunction after prolonged artificial respiration.

中文翻译：

隔膜的组织工程及其各种治疗可能性——系统评价

膈肌损伤表现出高发病率和死亡率，而目前的治疗方案仍然不能令人满意。组织工程 (TE) 方法已经探索了通过组织去细胞化或从头构建（添加或不添加细胞）生成用于膈肌修复的最佳生物相容性支架。作者对膈肌组织工程 (DTE) 的当前技术水平进行了系统评价，发现 24 篇符合最终合成条件的文章。所包含的方法研究了基于脱细胞的移植物生成 (9) 和从头生物支架构建 (9)。三项研究侧重于体外宿主-支架与合成的再细胞化移植物 (2) 和脱细胞细胞外基质支架 (1) 的相互作用。另外三项研究调查了脱细胞功效的评估工具。在所有研究中，再细胞化在基于去细胞化 (4) 和从头生成的支架 (4) 中进行。在所有检查的动物模型中，从头构建的生物复合材料以及脱细胞和再细胞化支架诱导促再生重塑和膈肌功能恢复。潜在的治疗应用包括需要修补的物质缺陷，例如先天性膈疝，以及需要整个器官移植的功能性疾病，例如长时间人工呼吸后的肌营养不良或功能障碍。在所有检查的动物模型中，从头构建的生物复合材料以及脱细胞和再细胞化支架诱导促再生重塑和膈肌功能恢复。潜在的治疗应用包括需要修补的物质缺陷，例如先天性膈疝，以及需要整个器官移植的功能性疾病，例如长时间人工呼吸后的肌营养不良或功能障碍。在所有检查的动物模型中，从头构建的生物复合材料以及脱细胞和再细胞化支架诱导促再生重塑和膈肌功能恢复。潜在的治疗应用包括需要修补的物质缺陷，例如先天性膈疝，以及需要整个器官移植的功能性疾病，例如长时间人工呼吸后的肌营养不良或功能障碍。

更新日期：2022-04-04

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