Ripples are brief high-frequency electrographic events with important roles in episodic memory. However, the in vivo circuit mechanisms coordinating ripple-related activity among local and distant neuronal ensembles are not well understood. Here, we define key characteristics of a long-distance projecting GABAergic cell group in the mouse hippocampus that selectively exhibits high-frequency firing during ripples while staying largely silent during theta-associated states when most other GABAergic cells are active. The high ripple-associated firing commenced before ripple onset and reached its maximum before ripple peak, with the signature theta-OFF, ripple-ON firing pattern being preserved across awake and sleep states. Controlled by septal GABAergic, cholinergic, and CA3 glutamatergic inputs, these ripple-selective cells innervate parvalbumin and cholecystokinin-expressing local interneurons while also targeting a variety of extra-hippocampal regions. These results demonstrate the existence of a hippocampal GABAergic circuit element that is uniquely positioned to coordinate ripple-related neuronal dynamics across neuronal assemblies.

波纹是短暂的高频电图事件，在情景记忆中具有重要作用。然而，体内协调局部和远距离神经元群之间的波纹相关活动的电路机制尚不清楚。在这里，我们定义了小鼠海马体中长距离投射 GABA 能细胞群的关键特征，该细胞群在波纹期间选择性地表现出高频放电，而在大多数其他 GABA 能细胞活跃时在 θ 相关状态下基本保持沉默。与纹波相关的高放电在纹波开始之前就开始了，并在纹波峰值之前达到了最大值，标志性的 theta-OFF、纹波开启的放电模式在清醒和睡眠状态下都得到了保留。由间隔 GABA 能、胆碱能和 CA3 谷氨酸能输入控制，这些波纹选择性细胞支配表达小白蛋白和胆囊收缩素的局部中间神经元，同时还针对各种海马外区域。