Taurine Alleviates Trimethylamine N-Oxide-Induced Atherosclerosis by Regulating Bile Acid Metabolism in ApoE–/– Mice,Journal of Agricultural and Food Chemistry

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Taurine Alleviates Trimethylamine N-Oxide-Induced Atherosclerosis by Regulating Bile Acid Metabolism in ApoE–/– Mice
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2022-04-29 , DOI: 10.1021/acs.jafc.2c01376
Jin-Yue Yang ₁ , Tian-Tian Zhang ₁ , Zhu-Lin Yu ₁ , Cheng-Cheng Wang ₁ , Ying-Cai Zhao ₁ , Yu-Ming Wang _{1,

2} , Chang-Hu Xue _{1,

2}

Affiliation

Trimethylamine N-oxide (TMAO) widely exists in seafood and is associated with the atherosclerosis progress, but dietary seafood reduced the cardiovascular risk. This intimates that there may be some ingredients in seafood to offset the cardiovascular risk caused by TMAO. Taurine is a marker ingredient in seafood. Thus, this study determined the influences of taurine on TMAO-induced atherosclerosis in apolipoprotein-E-deficient mice. The results showed that dietary taurine significantly reduced the TMAO-induced atherosclerotic lesion area. Further studies found that taurine increased the hepatic- and serum-conjugated bile acid/unconjugated bile acid ratio via increasing hepatic gene expression of conjugated bile acid synthesis. Meanwhile, taurine changed TMAO-induced abnormal bile acid profiles in the gallbladder. Moreover, taurine increased bile acid deconjugation by enhancing the genera Ruminiclostridium level and increased excretion of fecal neutral sterols. Additionally, taurine attenuated inflammation in the serum and artery. These results indicate that taurine alleviated TMAO-induced atherosclerosis via regulating bile acid metabolism.

中文翻译：

牛磺酸通过调节 ApoE–/– 小鼠的胆汁酸代谢来缓解三甲胺 N-氧化物诱导的动脉粥样硬化

三甲胺N-氧化物（TMAO）广泛存在于海产品中，与动脉粥样硬化的进展有关，但饮食中的海产品降低了心血管风险。这暗示海鲜中可能有一些成分可以抵消 TMAO 引起的心血管风险。牛磺酸是海鲜中的标志性成分。因此，本研究确定了牛磺酸对载脂蛋白 E 缺陷小鼠中 TMAO 诱导的动脉粥样硬化的影响。结果表明，膳食牛磺酸显着减少了TMAO诱导的动脉粥样硬化病变面积。进一步的研究发现，牛磺酸通过增加肝脏结合胆汁酸合成的基因表达，提高了肝脏和血清结合胆汁酸/非结合胆汁酸的比率。同时，牛磺酸改变了胆囊中 TMAO 诱导的异常胆汁酸谱。而且，瘤胃梭菌水平和粪便中性甾醇的排泄增加。此外，牛磺酸可减轻血清和动脉中的炎症。这些结果表明牛磺酸通过调节胆汁酸代谢来缓解 TMAO 诱导的动脉粥样硬化。

更新日期：2022-04-29

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