Background

The role of sortilin and omentin-1 in the pathogenesis of atherosclerosis and vascular disease is an emerging topic in recent years. These molecules can be found circulating in the blood. Recent studies have shown how these biomarkers appear to correlate with the severity of PAD. The levels of these molecules appear to be inversely proportional to each other. Their relationship may provide further insight into the management of the very old diabetic patients with PAD. This study aimed to assess the possible role of sortilin/omentin-1 ratio as easy-to-measure marker in peripheral artery disease (PAD) in type-2 diabetic patients.

Methods

This study analyzed the association between sortilin and omentin-1 serum levels and the presence of clinically significant lower limb PAD in diabetic individuals. We enrolled 295 diabetic patients, including 179 with PAD. Serum levels were collected and correlated with clinical characteristics of the patients.

Results

Sortilin concentration was significantly higher in the latter group compared to the former and there was a trend toward increased sortilin levels as disease severity increased. Omentin-1 serum levels were significantly lower in diabetic patients with PAD than in diabetic controls and the levels gradually decreased in proportion to disease severity. The ratio of sortilin to omentin-1 was significantly higher in patients with PAD compared to the other group.

Conclusion

The sortilin to omentin-1 ratio appears to be a predictive factor for PAD in patients with type-2 diabetes and it may be a promising marker for clinically significant atherosclerosis of the lower limbs. Further studies are needed to confirm this finding and to evaluate its clinical usefulness.

中文翻译：

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外周动脉疾病中的 Sortilin/Omentin-1 比率：对 295 名未选择的老年患者的横断面研究

背景

sortilin 和 omentin-1 在动脉粥样硬化和血管疾病发病机制中的作用是近年来新兴的课题。这些分子可以在血液中循环。最近的研究表明，这些生物标志物似乎与 PAD 的严重程度相关。这些分子的水平似乎彼此成反比。他们的关系可以进一步深入了解患有 PAD 的老年糖尿病患者的管理。本研究旨在评估 sortilin/omentin-1 比率作为易于测量的标记物在 2 型糖尿病患者外周动脉疾病 (PAD) 中的可能作用。

方法

本研究分析了血清分拣蛋白和 omentin-1 水平与糖尿病个体存在临床上显着的下肢 PAD 之间的关联。我们招募了 295 名糖尿病患者，其中 179 名患有 PAD。收集血清水平并将其与患者的临床特征相关联。

结果

与前者相比，后一组中的 Sortilin 浓度显着更高，并且随着疾病严重程度的增加，sortilin 水平有增加的趋势。患有 PAD 的糖尿病患者的 Omentin-1 血清水平显着低于糖尿病对照组，并且水平与疾病严重程度成比例逐渐下降。与另一组相比，PAD 患者的 sortilin 与 omentin-1 的比率显着升高。

结论

sortilin 与 omentin-1 的比率似乎是 2 型糖尿病患者 PAD 的预测因素，它可能是临床上显着的下肢动脉粥样硬化的有希望的标志物。需要进一步的研究来证实这一发现并评估其临床实用性。