Phosphoinositide signalling regulates cellular processes and is hijacked by pathogens. Classically, phosphoinositides are produced by kinase- and phosphatase-catalysed reactions. A study now reveals an unprecedented, kinase- and ATP-free synthesis of PtdIns(3,4)P2 via a phosphotransferase mechanism during bacterial infection.

中文翻译：

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磷酸肌醇磷酸化无激酶

磷酸肌醇信号调节细胞过程并被病原体劫持。经典地，磷酸肌醇由激酶和磷酸酶催化的反应产生。一项研究现在揭示了一种前所未有的、无激酶和无 ATP 的 PtdIns(3,4)P2 在细菌感染期间通过磷酸转移酶机制的合成。