Upcycling of carbon dioxide (CO₂) into value-added products represents a substantially untapped opportunity to tackle environmental issues and achieve a circular economy. Compared with easily available C₁/C₂ products, nevertheless, efficient and sustainable synthesis of energy-rich long-chain compounds from CO₂ still remains a grand challenge. Here we describe a hybrid electro-biosystem, coupling spatially separate CO₂ electrolysis with yeast fermentation, that efficiently converts CO₂ to glucose with a high yield. We employ a nanostructured copper catalyst that can stably catalyse pure acetic acid production with a solid-electrolyte reactor. We then genetically engineer Saccharomyces cerevisiae to produce glucose in vitro from electro-generated acetic acid by deleting all defined hexokinase genes and overexpression of heterologous glucose-1-phosphatase. In addition, we showcase that the proposed platform can be easily extended to produce other products like fatty acids using CO₂ as the carbon source. These results illuminate the tantalizing possibility of a renewable-electricity-driven manufacturing industry.

将二氧化碳 (CO ₂ ) 升级为增值产品是解决环境问题和实现循环经济的一个尚未开发的机会。然而，与容易获得的 C ₁ /C _{2产品相比，从 CO 2}高效且可持续地合成富含能量的长链化合物仍然是一个巨大的挑战。在这里，我们描述了一种混合电生物系统，将空间分离的 CO ₂电解与酵母发酵相结合，以高产率有效地将 CO _{2转化为葡萄糖。}我们采用了一种纳米结构的铜催化剂，可以通过固体电解质反应器稳定地催化纯乙酸的生产。然后我们进行基因工程Saccharomyces cerevisiae通过删除所有已定义的己糖激酶基因和异源葡萄糖-1-磷酸酶的过表达，在体外从电产生的乙酸中产生葡萄糖。_{此外，我们展示了所提出的平台可以轻松扩展以生产其他产品，例如使用 CO 2}作为碳源的脂肪酸。这些结果阐明了可再生电力驱动的制造业的诱人可能性。