Facile Preparation of Polysaccharide−Polypeptide Conjugates via a Biphasic Solution Ring-Opening Polymerization,ACS Macro Letters

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Facile Preparation of Polysaccharide−Polypeptide Conjugates via a Biphasic Solution Ring-Opening Polymerization
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-04-28 , DOI: 10.1021/acsmacrolett.2c00205
Fangping Yang ₁ , Zhiwei Liu ₁ , Wenting Si ₁ , Ziyuan Song ₁ , Lichen Yin ₁ , Haoyu Tang ₁

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Polysaccharide–polypeptide conjugates have gained a broad interest in mimicking the structure and bioactivity of peptidoglycans or proteoglycans for biomedical applications. Efficient and precise preparation of the conjugates is challenging and unresolved, mainly because of the mismatched solubility between polysaccharide initiators and N-carboxyanhydrides (NCAs), which frequently results in competing side reactions and oligomeric polypeptide chain. Herein, we report a facile and efficient strategy to prepare the conjugates with well-controlled polypeptide chain length (l_p) directly from unmodified polysaccharides via a biphasic solution ring-opening polymerization. The effect of l_p on surface antibacterial properties has been investigated. Elongating the l_p can significantly potentiate the antibiofilm property of the conjugate coatings. Our results may provide opportunities to develop various polypeptide-based conjugates with well-defined structures toward versatile uses.

中文翻译：

通过双相溶液开环聚合轻松制备多糖-多肽偶联物

多糖-多肽缀合物在模拟用于生物医学应用的肽聚糖或蛋白聚糖的结构和生物活性方面引起了广泛的兴趣。缀合物的高效和精确制备具有挑战性且尚未解决，主要是因为多糖引发剂和N-羧基酸酐 (NCA) 之间的溶解度不匹配，这经常导致竞争性副反应和寡聚多肽链。在此，我们报告了一种简便有效的策略，可通过双相溶液开环聚合直接从未修饰的多糖中制备具有良好控制的多肽链长度 ( l _{p ) 的缀合物。}l _p的影响对表面抗菌性能进行了研究。延长l _p可以显着增强缀合物涂层的抗生物膜特性。我们的结果可能为开发各种基于多肽的缀合物提供了机会，这些缀合物具有明确的结构，可用于多种用途。

更新日期：2022-04-28

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