Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease,Alzheimer's & Dementia

当前位置： X-MOL 学术 › Alzheimers Dement. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2022-04-28 , DOI: 10.1002/alz.12675
Rui Chang _{1,

2} , Eugenia Trushina _{3,

4} , Kuixi Zhu _{1,

2} , Syed Shujaat Ali Zaidi _{1,

2} , Branden M Lau ₅ , Alexandra Kueider-Paisley ₆ , Sara Moein _{2,

7} , Qianying He ₈ , Melissa L Alamprese ₂ , Barbora Vagnerova ₉ , Andrew Tang ₁₀ , Ramachandran Vijayan ₁ , Yanyun Liu ₁ , Andrew J Saykin ₁₁ , Roberta D Brinton _{1,

2,

9} , Rima Kaddurah-Daouk _{6,

12,

13} , ₁

Affiliation

Department of Neurology, University of Arizona, Tucson, Arizona, USA.
The Center for Innovation in Brain Science, University of Arizona, Tucson, Arizona, USA.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA.
Arizona Research Labs, Genetics Core, University of Arizona, Tucson, Arizona, USA.
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA.
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USA.
Department of Biosystems Engineering, University of Arizona, Tucson, Arizona, USA.
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona, USA.
Department of Neuroscience, University of Arizona, Tucson, Arizona, USA.
Department of Radiology and Imaging Sciences and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Duke Institute of Brain Sciences, Duke University, Durham, North Carolina, USA.
Department of Medicine, Duke University, Durham, North Carolina, USA.

Late-onset Alzheimer's disease (LOAD) is a complex neurodegenerative disease characterized by multiple progressive stages, glucose metabolic dysregulation, Alzheimer's disease (AD) pathology, and inexorable cognitive decline. Discovery of metabolic profiles unique to sex, apolipoprotein E (APOE) genotype, and stage of disease progression could provide critical insights for personalized LOAD medicine.

中文翻译：

预测代谢网络揭示了性别和 APOE 基因型特异性代谢特征以及阿尔茨海默病精准医疗的驱动因素

晚发性阿尔茨海默病 (LOAD) 是一种复杂的神经退行性疾病，其特征为多个进展阶段、葡萄糖代谢失调、阿尔茨海默病 (AD) 病理和不可阻挡的认知能力下降。性别、载脂蛋白 E ( APOE ) 基因型和疾病进展阶段特有的代谢特征的发现可以为个性化 LOAD 医学提供重要的见解。

更新日期：2022-04-28

点击分享查看原文

点击收藏

阅读更多本刊最新论文