Anti-Diabetic Intestinal Mechanisms: Foods, Herbs, and Western Medicines,Molecular Nutrition & Food Research

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Anti-Diabetic Intestinal Mechanisms: Foods, Herbs, and Western Medicines
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2022-04-28 , DOI: 10.1002/mnfr.202200106
Yuwei Feng _{1,

2} , Hong Cao _{1,

2,

3,

4} , Jiao Hua _{2,

5} , Feng Zhang _{1,

2,

3,

6}

Affiliation

The role of intestinal factors in the pathogenesis of diabetes, such as a decrease in the incretin effect, has recently attracted considerable attention. An imbalance in the gut microbiota inhibits the secretion of incretins, which are metabolic hormones can reduce blood glucose levels, and promotes the occurrence and development of diabetes. Numerous studies have demonstrated that foods are environmental factors that are important in the modulation of gut microbial-mediated glucose metabolism. In general, functional foods trigger the gut microbiota to produce beneficial metabolites or reduce harmful products through metabolic pathways and then regulate glucose and lipid metabolism. Recent studies have shown that similar to functional foods, the regulatory effects of some herbs and Western medicines are closely related to alterations in the gut microbiota. In this review, the intestinal mechanism of foods, herbs, and Western medicine in affecting the process of glucose metabolism is summarized.

中文翻译：

抗糖尿病肠道机制：食物、草药和西药

肠道因素在糖尿病发病机制中的作用，例如肠促胰岛素作用的降低，最近引起了相当多的关注。肠道菌群失衡会抑制肠促胰岛素的分泌，肠促胰岛素是一种代谢激素，可以降低血糖水平，促进糖尿病的发生和发展。大量研究表明，食物是调节肠道微生物介导的葡萄糖代谢的重要环境因素。一般来说，功能性食品通过代谢途径触发肠道菌群产生有益代谢物或减少有害产物，进而调节糖脂代谢。最近的研究表明，与功能性食品类似，一些草药和西药的调节作用与肠道菌群的改变密切相关。本文综述了食物、草药和西药影响糖代谢过程的肠道机制。

更新日期：2022-04-28

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