A Therapeutic Sheep in Metastatic Wolf’s Clothing: Trojan Horse Approach for Cancer Brain Metastases Treatment,Nano-Micro Letters

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A Therapeutic Sheep in Metastatic Wolf’s Clothing: Trojan Horse Approach for Cancer Brain Metastases Treatment
Nano-Micro Letters ( IF 31.6 ) Pub Date : 2022-04-28 , DOI: 10.1007/s40820-022-00861-1
Hai-Jun Liu ₁ , Mingming Wang ₁ , Shanshan Shi ₁ , Xiangxiang Hu ₁ , Peisheng Xu ₁

Affiliation

DOX-PLGA@CM employs the whole set of membrane molecules of a brain-homing metastatic breast cancer cell optimized through a natural selection process. Thus, the hetero and multivalent effects of these molecules greatly facilitate the nanoparticle crossing the blood-brain barrier.
Attributed to the homotypic effect of the nanocarrier, DOX-PLGA@CM shows stronger anticancer efficacy than free DOX for its parenteral cells.
DOX-PLGA@CM effectively reaches the metastatic tumor lesions in the brain, and slows down the progression of brain metastatic breast cancer.

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