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A Therapeutic Sheep in Metastatic Wolf’s Clothing: Trojan Horse Approach for Cancer Brain Metastases Treatment
Nano-Micro Letters ( IF 31.6 ) Pub Date : 2022-04-28 , DOI: 10.1007/s40820-022-00861-1
Hai-Jun Liu 1 , Mingming Wang 1 , Shanshan Shi 1 , Xiangxiang Hu 1 , Peisheng Xu 1
Affiliation  

  • DOX-PLGA@CM employs the whole set of membrane molecules of a brain-homing metastatic breast cancer cell optimized through a natural selection process. Thus, the hetero and multivalent effects of these molecules greatly facilitate the nanoparticle crossing the blood-brain barrier.

  • Attributed to the homotypic effect of the nanocarrier, DOX-PLGA@CM shows stronger anticancer efficacy than free DOX for its parenteral cells.

  • DOX-PLGA@CM effectively reaches the metastatic tumor lesions in the brain, and slows down the progression of brain metastatic breast cancer.



中文翻译:


披着转移狼外衣的治疗羊:癌症脑转移治疗的特洛伊木马方法



  • DOX-PLGA@CM 采用通过自然选择过程优化的脑归巢转移性乳腺癌细胞的整套膜分子。因此,这些分子的异质和多价效应极大地促进了纳米颗粒穿过血脑屏障。


  • 由于纳米载体的同型效应,DOX-PLGA@CM对其肠胃外细胞表现出比游离DOX更强的抗癌功效。


  • DOX-PLGA@CM有效到达脑部转移性肿瘤病灶,减缓脑转移性乳腺癌的进展。

更新日期:2022-04-29
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