Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease,Journal of Advanced Research

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Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease
Journal of Advanced Research ( IF 11.4 ) Pub Date : 2022-04-28 , DOI: 10.1016/j.jare.2022.04.013
Pamela Houeiss ₁ , Rachel Njeim ₁ , Hani Tamim ₂ , Ahmed F Hamdy ₃ , Tanya S Azar ₁ , William S Azar ₄ , Mohamed Noureldein ₁ , Youssef H Zeidan ₅ , Awad Rashid ₃ , Sami T Azar ₆ , Assaad A Eid ₁

Affiliation

Introduction

The identification and validation of a non-invasive prognostic marker for early detection of diabetic kidney disease (DKD) can lead to substantial improvement in therapeutic decision-making.

Objectives

The main objective of this study is to assess the potential role of the arachidonic acid (AA) metabolite 20-hydroxyeicosatetraenoic (20-HETE) in predicting the incidence and progression of DKD.

Methods

Healthy patients and patients with diabetes were recruited from the Hamad General Hospital in Qatar, and urinary 20-HETE levels were measured. Data analysis was done using the Statistical Package for Social Sciences (SPSS).

Results

Our results show that urinary 20-HETE-to-creatinine (20-HETE/Cr) ratios were significantly elevated in patients with DKD when compared to patients with diabetes who did not exhibit clinical signs of kidney injury (p < 0.001). This correlation was preserved in the multivariate linear regression accounting for age, diabetes, family history of kidney disease, hypertension, dyslipidemia, stroke and metabolic syndrome. Urinary 20-HETE/Cr ratios were also positively correlated with the severity of kidney injury as indicated by albuminuria levels (p < 0.001). A urinary 20-HETE/Cr ratio of 4.6 pmol/mg discriminated between the presence and absence of kidney disease with a sensitivity of 82.2 % and a specificity of 67.1%. More importantly, a 10-unit increase in urinary 20-HETE/Cr ratio was tied to a 10-fold increase in the risk of developing DKD, suggesting a 20-HETE prognostic efficiency.

Conclusion

Taken together, our results suggest that urinary 20-HETE levels can potentially be used as non-invasive diagnostic and prognostic markers for DKD.

中文翻译：

尿 20-HETE：糖尿病肾病的前瞻性非侵入性预后和诊断标志物

介绍

识别和验证用于早期检测糖尿病肾病（DKD）的非侵入性预后标志物可以显着改善治疗决策。

目标

本研究的主要目的是评估花生四烯酸 (AA) 代谢物 20-羟基二十碳四烯酸 (20-HETE) 在预测 DKD 发病和进展中的潜在作用。

方法

从卡塔尔哈马德综合医院招募健康患者和糖尿病患者，并测量尿 20-HETE 水平。使用社会科学统计软件包（SPSS）进行数据分析。

结果

我们的结果表明，与未表现出肾损伤临床症状的糖尿病患者相比，DKD 患者尿 20-HETE 与肌酐 (20-HETE/Cr) 的比率显着升高 ( p < 0.001)。这种相关性在考虑年龄、糖尿病、肾病家族史、高血压、血脂异常、中风和代谢综合征的多元线性回归中得以保留。尿 20-HETE/Cr 比率也与肾损伤的严重程度呈正相关，如蛋白尿水平所示 ( p < 0.001)。尿 20-HETE/Cr 比率为 4.6 pmol/mg 可区分是否存在肾脏疾病，敏感性为 82.2%，特异性为 67.1%。更重要的是，尿 20-HETE/Cr 比率增加 10 个单位与患 DKD 的风险增加 10 倍相关，这表明 20-HETE 的预后效率。