The successful transplantation of stem cells has the potential to transform regenerative medicine approaches and open promising avenues to repair, replace, and regenerate diseased, damaged, or aged tissues. However, pre-/post-transplantation issues of poor cell survival, retention, cell fate regulation, and insufficient integration with host tissues constitute significant challenges. The success of stem cell transplantation depends upon the coordinated sequence of stem cell renewal, specific lineage differentiation, assembly, and maintenance of long-term function. Advances in biomaterials can improve pre-/post-transplantation outcomes by integrating biophysiochemical cues and emulating tissue microenvironments. This review highlights leading biomaterials-based approaches for enhancing stem cell transplantation.

干细胞的成功移植有可能改变再生医学方法，并为修复、替换和再生患病、受损或老化的组织开辟有希望的途径。然而，移植前/移植后的细胞存活、保留、细胞命运调节不良以及与宿主组织整合不足等问题构成了重大挑战。干细胞移植的成功取决于干细胞更新、特定谱系分化、组装和长期功能维持的协调顺序。生物材料的进步可以通过整合生物生理化学线索和模拟组织微环境来改善移植前/后的结果。本综述重点介绍了基于生物材料的增强干细胞移植的领先方法。