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Selective Photochemical Continuous Flow Benzylic Monochlorination
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2022-04-27 , DOI: 10.1021/acs.oprd.2c00065 Robbie Radjagobalou 1 , Miguel Imbratta 2 , Julie Bergraser 2 , Marion Gaudeau 2 , Gildas Lyvinec 2 , Dominique Delbrayelle 2 , Olivier Jentzer 2 , Jérémy Roudin 1 , Benjamin Laroche 1 , Stéphanie Ognier 1 , Michael Tatoulian 1 , Janine Cossy 1 , Pierre-Georges Echeverria 2
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2022-04-27 , DOI: 10.1021/acs.oprd.2c00065 Robbie Radjagobalou 1 , Miguel Imbratta 2 , Julie Bergraser 2 , Marion Gaudeau 2 , Gildas Lyvinec 2 , Dominique Delbrayelle 2 , Olivier Jentzer 2 , Jérémy Roudin 1 , Benjamin Laroche 1 , Stéphanie Ognier 1 , Michael Tatoulian 1 , Janine Cossy 1 , Pierre-Georges Echeverria 2
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A selective photochemical monochlorination of 2-fluorotoluene has been developed by a continuous flow process using two different flow reactors, one for the tuning of the conditions and the second one for the scale-up. The key reaction parameters were optimized using one-factor-at-a-time and design of experiment methods, with the goal of minimizing the formation of the dichlorinated by-product. This transformation has been performed on a multi decagram scale.
中文翻译：
选择性光化学连续流动苄基一氯化
2-氟甲苯的选择性光化学单氯化已经通过使用两个不同流动反应器的连续流动工艺开发，一个用于调节条件，第二个用于放大。使用一次一个因素和设计实验方法来优化关键反应参数，目标是尽量减少二氯代副产物的形成。这种转换已经在多十克尺度上进行。
更新日期：2022-04-27
中文翻译：
选择性光化学连续流动苄基一氯化
2-氟甲苯的选择性光化学单氯化已经通过使用两个不同流动反应器的连续流动工艺开发，一个用于调节条件，第二个用于放大。使用一次一个因素和设计实验方法来优化关键反应参数，目标是尽量减少二氯代副产物的形成。这种转换已经在多十克尺度上进行。
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