The significant clinical feature of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is the exposure of the necrotic jaw. Other clinical manifestations include jaw pain, swelling, abscess, and skin fistula, which seriously affect the patients’ life, and there is no radical cure. Thus, new methods need to be found to prevent the occurrence of BRONJ. Here, a novel nanoparticle, tFNA-KLT, was successfully synthesized by us, in which the nanoparticle tetrahedral framework nucleic acid (tFNA) was used for carrying angiogenic peptide, KLT, and then further enhanced angiogenesis. TFNA-KLT possessed the same characteristics as tFNA, such as simple synthesis, stable structure, and good biocompatibility. Meanwhile, tFNA enhanced the stability of KLT and carried more KLT to interact with endothelial cells. First, it was confirmed that tFNA-KLT had the superior angiogenic ability to tFNA and KLT both in vitro and in vivo. Then we apply tFNA-KLT to the prevention of BRONJ. The results showed that tFNA-KLT can effectively prevent the occurrence of BRONJ by accelerating angiogenesis. In summary, the prepared novel nanoparticle, tFNA-KLT, was firstly synthesized by us. It was also firstly confirmed by us that tFNA-KLT significantly enhanced angiogenesis and can effectively prevent the occurrence of BRONJ by accelerating angiogenesis, thus providing a new avenue for the prevention of BRONJ and a new choice for therapeutic angiogenesis.

双膦酸盐相关颌骨坏死 (BRONJ) 的重要临床特征是坏死颌骨的暴露。其他临床表现有颌骨疼痛、肿胀、脓肿、皮肤瘘管等，严重影响患者生活，目前尚无根治方法。因此，需要找到新的方法来预防 BRONJ 的发生。在这里，我们成功合成了一种新型纳米颗粒tFNA-KLT，其中纳米颗粒四面体骨架核酸（tFNA）用于携带血管生成肽KLT，然后进一步增强血管生成。TFNA-KLT具有与tFNA相同的合成简单、结构稳定、生物相容性好的特点。同时，tFNA 增强了 KLT 的稳定性，并携带更多的 KLT 与内皮细胞相互作用。第一的，证实 tFNA-KLT 在体外和体内均具有优于 tFNA 和 KLT 的血管生成能力。然后我们将 tFNA-KLT 应用于 BRONJ 的预防。结果表明，tFNA-KLT可通过加速血管生成有效预防BRONJ的发生。总之，制备的新型纳米粒子tFNA-KLT是我们首次合成的。我们也首次证实，tFNA-KLT可显着增强血管生成，通过加速血管生成有效预防BRONJ的发生，为预防BRONJ提供了新途径，为治疗性血管生成提供了新选择。结果表明，tFNA-KLT可通过加速血管生成有效预防BRONJ的发生。总之，制备的新型纳米粒子tFNA-KLT是我们首次合成的。我们也首次证实，tFNA-KLT可显着增强血管生成，通过加速血管生成有效预防BRONJ的发生，为预防BRONJ提供了新途径，为治疗性血管生成提供了新选择。结果表明，tFNA-KLT可通过加速血管生成有效预防BRONJ的发生。总之，制备的新型纳米粒子tFNA-KLT是我们首次合成的。我们也首次证实，tFNA-KLT可显着增强血管生成，通过加速血管生成有效预防BRONJ的发生，为预防BRONJ提供了新途径，为治疗性血管生成提供了新选择。