Archives of Environmental Contamination and Toxicology ( IF 3.7 ) Pub Date : 2022-04-25 , DOI: 10.1007/s00244-022-00924-9 Jeongeun Im 1 , Hyun-Jeong Eom 1 , Jinhee Choi 1
|
Microplastic contamination has received increasing attention in recent years, and concern regarding the toxicity of microplastics to the environment and humans has increased. In this study, we investigated the neurodevelopmental toxicity of polystyrene microplastics (PSMPs) in the zebrafish Danio rerio under different exposure scenarios. Zebrafish were exposed to PSMPs during embryonic stage and then allowed the fish to recover. The neurodevelopmental toxic responses were investigated using fish behavior and behavior-related gene expression. Early-life exposure to PSMPs did not alter fish behavior at the early stage; however, it led to hyperactivity later life stage. Generally, oxidative stress (i.e., sod2 and nrf2a)- and nervous system (i.e., slc6a4b, npy, and nrbf2)-related gene expression increased in all PSMPs-exposed fish. DNA hypomethylation was observed in fish challenged for a second time using the same PSMPs. Taken together, the current results imply that PSMPs have neurodevelopmental toxic potential when introduced early in life.
Graphical Abstract
中文翻译：
聚苯乙烯微塑料的早期暴露对斑马鱼后期行为和 DNA 甲基化的影响
近年来，微塑料污染越来越受到关注，对微塑料对环境和人类的毒性的关注也越来越多。在这项研究中，我们调查了斑马鱼斑马鱼斑马鱼在不同暴露情景下聚苯乙烯微塑料 (PSMPs) 的神经发育毒性。斑马鱼在胚胎阶段暴露于 PSMP，然后让鱼恢复。使用鱼类行为和行为相关基因表达研究了神经发育毒性反应。早期接触 PSMP 并没有改变早期鱼类的行为；然而，它导致了生命后期的多动症。一般来说，氧化应激（即sod2和nrf2a）和神经系统（即slc6a4b、npy和nrbf2)相关基因表达在所有暴露于 PSMP 的鱼中增加。在使用相同 PSMP 进行第二次攻击的鱼中观察到 DNA 低甲基化。总之，目前的结果表明 PSMP 在生命早期引入时具有神经发育毒性潜力。
京公网安备 11010802027423号