The gut microbiome is a contributory factor in ageing-related health loss and in several non-communicable diseases in all age groups. Some age-linked and disease-linked compositional and functional changes overlap, while others are distinct. In this Review, we explore targeted studies of the gut microbiome of older individuals and general cohort studies across geographically distinct populations. We also address the promise of the targeted restoration of microorganisms associated with healthier ageing.

中文翻译：

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肠道微生物组作为健康衰老的调节剂

肠道微生物组是所有年龄组中与衰老相关的健康损失和多种非传染性疾病的促成因素。一些与年龄相关和与疾病相关的成分和功能变化重叠，而另一些则是截然不同的。在这篇综述中，我们探索了针对老年人肠道微生物组的针对性研究以及跨地理不同人群的一般队列研究。我们还承诺有针对性地恢复与健康老龄化相关的微生物。