Recent reports of SARS-CoV-2 Omicron variant sub-lineages, BA.1, BA.1.1, and BA.2, have reignited concern over potential escape from vaccine- and infection-induced immunity. We examine the sensitivity of these sub-lineages and other major variants to neutralizing antibodies from mRNA-vaccinated and boosted individuals, as well as recovered COVID-19 patients, including those infected with Omicron. We find that all Omicron sub-lineages, especially BA.1 and BA.1.1, exhibit substantial immune escape that is largely overcome by mRNA vaccine booster doses. While Omicron BA.1.1 escapes almost completely from neutralization by early-pandemic COVID-19 patient sera and to a lesser extent from sera of Delta-infected patients, BA.1.1 is sensitive to Omicron-infected patient sera. Critically, all Omicron sub-lineages, including BA.2, are comparably neutralized by Omicron patient sera. These results highlight the importance of booster vaccine doses for protection against all Omicron variants and provide insight into the immunity from natural infection against Omicron sub-lineages.

最近关于 SARS-CoV-2 Omicron 变异亚谱系 BA.1、BA.1.1 和 BA.2 的报道再次引发了人们对疫苗和感染诱导的免疫可能逃逸的担忧。我们检查了这些亚谱系和其他主要变体对中和来自 mRNA 疫苗接种和增强个体以及康复的 COVID-19 患者（包括感染 Omicron 的患者）的抗体的敏感性。我们发现所有 Omicron 亚谱系，尤其是 BA.1 和 BA.1.1，都表现出大量的免疫逃逸，这在很大程度上被 mRNA 疫苗加强剂量所克服。虽然 Omicron BA.1.1 几乎完全摆脱了早期大流行 COVID-19 患者血清的中和作用，并且在较小程度上摆脱了 Delta 感染患者的血清，但 BA.1.1 对 Omicron 感染的患者血清敏感。至关重要的是，所有 Omicron 子谱系，包括 BA.2，被 Omicron 患者血清中和。这些结果突出了加强疫苗剂量对保护所有 Omicron 变体的重要性，并提供了对自然感染对 Omicron 亚谱系的免疫力的洞察力。