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Near-Infrared-Driven Plasmon-Enhanced Au@PtAg Cascade Nanozymes for Cancer Therapy
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2022-04-24 , DOI: 10.1021/acsanm.2c00961 Jie Zhou 1 , Xue-Jiao Yang 2 , Qiao Yu 1 , Xiang-Ling Li 3 , Hong-Yuan Chen 1 , Jing-Juan Xu 1
ACS Applied Nano Materials ( IF 5.3 ) Pub Date : 2022-04-24 , DOI: 10.1021/acsanm.2c00961 Jie Zhou 1 , Xue-Jiao Yang 2 , Qiao Yu 1 , Xiang-Ling Li 3 , Hong-Yuan Chen 1 , Jing-Juan Xu 1
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Nanozymes with cascade catalytic reactions gain advantages over natural enzymes by simplifying the preparation, decreasing the cost, and enhancing the local concentrations of the intermediates and the stability. However, in vivo applications of such cascade nanozymes are hampered due to the low catalytic activity in the complex physiological microenvironment. Substantial research work is currently devoted to exploiting light-driven catalytic kinetic acceleration of nanozymes via hot electron injection from plasmonic nanoparticles. Here, a near-infrared (NIR) light-driven plasmon-enhanced cascade nanozyme with a formulation of Au@Pt0.46Ag0.54 is developed for efficient synergistic cancer therapy. This nanozyme possesses catalase, oxidase, and peroxidase activities and is capable of converting hydrogen peroxide to oxygen and reactive oxygen species through cascade reactions. Both in vitro and in vivo experimental measurements reveal that 808 nm NIR-laser-driven hot electron injection not only obviously enhanced the catalytic activities of the nanozyme but also triggered efficient photothermal conversion, which successfully achieved synergetic catalytic therapy/photothermal therapy for cancer treatment. This strategy of tailoring multi-metal cascade nanozyme techniques opens up avenues for realizing multistep reactions with high catalytic kinetics and provides an innovative way for therapeutic systems with clinical significance.
中文翻译：
用于癌症治疗的近红外驱动等离子体增强 Au@PtAg 级联纳米酶
具有级联催化反应的纳米酶通过简化制备、降低成本、提高中间体的局部浓度和稳定性而获得优于天然酶的优势。然而，由于在复杂的生理微环境中催化活性低，这种级联纳米酶的体内应用受到了阻碍。目前大量的研究工作致力于通过等离子体纳米粒子的热电子注入来利用光驱动的纳米酶催化动力学加速。在这里，一种近红外 (NIR) 光驱动等离子体增强级联纳米酶具有 Au@Pt 0.46 Ag 0.54的配方是为有效的协同癌症治疗而开发的。这种纳米酶具有过氧化氢酶、氧化酶和过氧化物酶活性，能够通过级联反应将过氧化氢转化为氧气和活性氧。体外和体内实验测量均表明，808 nm 近红外激光驱动的热电子注入不仅显着增强了纳米酶的催化活性，而且触发了高效的光热转化，成功实现了协同催化疗法/光热疗法治疗癌症。这种定制多金属级联纳米酶技术的策略为实现具有高催化动力学的多步反应开辟了途径，并为具有临床意义的治疗系统提供了创新途径。
更新日期：2022-04-24
中文翻译：
用于癌症治疗的近红外驱动等离子体增强 Au@PtAg 级联纳米酶
具有级联催化反应的纳米酶通过简化制备、降低成本、提高中间体的局部浓度和稳定性而获得优于天然酶的优势。然而，由于在复杂的生理微环境中催化活性低，这种级联纳米酶的体内应用受到了阻碍。目前大量的研究工作致力于通过等离子体纳米粒子的热电子注入来利用光驱动的纳米酶催化动力学加速。在这里，一种近红外 (NIR) 光驱动等离子体增强级联纳米酶具有 Au@Pt 0.46 Ag 0.54的配方是为有效的协同癌症治疗而开发的。这种纳米酶具有过氧化氢酶、氧化酶和过氧化物酶活性，能够通过级联反应将过氧化氢转化为氧气和活性氧。体外和体内实验测量均表明，808 nm 近红外激光驱动的热电子注入不仅显着增强了纳米酶的催化活性，而且触发了高效的光热转化，成功实现了协同催化疗法/光热疗法治疗癌症。这种定制多金属级联纳米酶技术的策略为实现具有高催化动力学的多步反应开辟了途径，并为具有临床意义的治疗系统提供了创新途径。
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