An electrochemical method has been developed for a mediated oxidation of primary alcohols to carboxylic acids. The method is compatible with a variety of alcohols bearing nitrogen-containing heterocycles in undivided batch and flow modes. The use of a heterogeneous NiOOH electron–proton transfer mediator avoids the need for homogeneous catalysts that contribute to more unit operations during downstream purging and increased process mass intensity. To demonstrate the applicability of this method for continuous processing, a single-pass flow electrochemical oxidation of nicotinyl alcohol to nicotinic acid is demonstrated with a 77% isolated yield. The NiOOH-coated anodes show no reduction in catalysis efficiency over 12 h, and minimal Ni metal leaching (22.3 μg per liter) is observed.

中文翻译：

---

以氢氧化镍为多相电催化剂的间歇式和连续流动式电化学氧化醇

已经开发了一种用于将伯醇介导氧化成羧酸的电化学方法。该方法适用于多种带有含氮杂环的醇，采用不分批和流动模式。使用非均相 NiOOH 电子-质子转移介质避免了对均相催化剂的需求，这些催化剂有助于在下游吹扫过程中进行更多单元操作并增加工艺质量强度。为了证明该方法在连续加工中的适用性，证明了将烟醇单程流电化学氧化为烟酸，分离产率为 77%。NiOOH 涂层阳极在 12 小时内没有显示催化效率降低，并且观察到最小的镍金属浸出（22.3 μg/升）。