The circulating precursor cells that give rise to human resident memory T cells (T RM ) are poorly characterized. We used an in vitro differentiation system and human skin–grafted mice to study T RM generation from circulating human memory T cell subsets. In vitro T RM differentiation was associated with functional changes, including enhanced IL-17A production and FOXP3 expression in CD4 + T cells and granzyme B production in CD8 + T cells, changes that mirrored the phenotype of T cells in healthy human skin. Effector memory T cells (T EM ) had the highest conversion rate to T RM in vitro and in vivo, but central memory T cells (T CM ) persisted longer in the circulation, entered the skin in larger numbers, and generated increased numbers of T RM . In summary, T CM are highly efficient precursors of human skin T RM , a feature that may underlie their known association with effective long-term immunity.

中文翻译：

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中央记忆 T 细胞是人体皮肤中常驻记忆 T 细胞最有效的前体

产生人类驻留记忆 T 细胞 (TR M) 特征不佳。我们使用体外分化系统和人类皮肤移植小鼠来研究 TR M从循环人类记忆 T 细胞亚群生成。体外试验R M分化与功能变化相关，包括增强的 IL-17A 产生和 CD4 中的 FOXP3 表达+CD8 中的 T 细胞和颗粒酶 B 的产生+T 细胞，反映健康人体皮肤中 T 细胞表型的变化。效应记忆 T 细胞 (T电磁波) 对 T 的转化率最高R M在体外和体内，但中央记忆 T 细胞 (T厘米) 在循环中持续时间更长，更多地进入皮肤，并产生更多的 TR M. 总之，T厘米是人类皮肤 T 的高效前体R M，这一特征可能是它们与有效长期免疫力已知关联的基础。