Metal-organic frameworks (MOFs) endowed with unique structural features, namely permanent porosity, high surface area, tunable pore size, and potential applications in diverse domains, have garnered immense attention in recent decades. The availability of large numbers of organic linkers, metal nodes, and multiple synthetic tactics has broadened the scope of MOF research wherein the judicial selection of building blocks, and especially the organic linker is critical for the task-specific MOF design. The adenine nucleobase is an ideal choice among the broadly available organic linkers because of its small size, being nitrogen-riched and non-toxic, and its ready availability comprising multiple Lewis basic coordination sites and modes. In addition, adenine with its amino group (–NH₂) can network through non-covalent interfaces (host and guest) rather than covalent interactions, i.e., hydrogen bonding via Watson-Crick (N1, N6H) and Hoogsteen (N7, N6H) face contact, thus making ensued adenine-based MOF materials more appealing. Herein, we appraise the general introduction of syntheses and design strategies, the structural influence of adenine incorporation to the ensued attributes of MOFs, and their applications in diverse research fields such as gas storage (selective adsorption of CO₂), separation, luminescence, drug delivery, catalysis, and sensing.

金属有机框架（MOFs）具有独特的结构特征，即永久孔隙率、高表面积、可调孔径以及在不同领域的潜在应用，近几十年来引起了极大的关注。大量有机连接器、金属节点和多种合成策略的可用性扩大了 MOF 研究的范围，其中构建块的司法选择，尤其是有机连接器对于特定任务的 MOF 设计至关重要。腺嘌呤核碱基是广泛可用的有机接头中的理想选择，因为它体积小、富含氮且无毒，并且其包含多个路易斯基本配位位点和模式的现成可用性。此外，腺嘌呤及其氨基（-NH ₂) 可以通过非共价界面（主体和客体）而不是共价相互作用建立网络，即通过 Watson-Crick (N1, N6H) 和 Hoogsteen (N7, N6H) 面接触形成氢键，从而使基于腺嘌呤的 MOF 材料更加吸引人。在此，我们评价了合成和设计策略的一般介绍，腺嘌呤掺入对 MOFs 属性的结构影响，以及它们在气体存储（CO ₂的选择性吸附）、分离、发光、药物等不同研究领域的应用。传递、催化和传感。