Objective: Chile is one of the few high-income countries in Latin America, being a pioneer in implementing a national newborn screening (NBS) program in 1992. Currently, it covers 98% of the population, but no long term outcomes have been described so far. The aim of this study is to report the neurocognitive outcomes of children with congenital hypothyroidism (CH) diagnosed by the NBS program in Chile between 2005 and 2012 and to identify variables associated with the outcomes. Methods: We performed a case control study in children with CH born in the two largest regions of the country. The Leiter-R and TEVI-R tests were administered at home to 69 children with CH and 68 matched control subjects. Other variables affecting cognition were obtained. Multivariate logistic regression analyses were performed for Leiter-R and TEVI-R tests, using a model for cases alone and another model for cases and controls. Results: No differences in Leiter-R and TEVI-R results were observed between children with CH and the control group. Children who performed better, regardless of whether they had CH, had a higher family income and more assets. Conclusions: These results suggest that the Chilean NBS program strategy results in children with normal language, attention and memory development. Socioeconomic disadvantage represents a significant detriment in cognitive function.


中文翻译：

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先天性甲状腺功能减退症的认知结果：社会经济地位的影响。病例对照研究

目标：智利是拉丁美洲为数不多的高收入国家之一，是 1992 年实施国家新生儿筛查 (NBS) 计划的先驱。目前，该计划覆盖了 98% 的人口，但尚未描述长期结果至今。本研究的目的是报告 2005 年至 2012 年间智利 NBS 项目诊断的先天性甲状腺功能减退症 (CH) 儿童的神经认知结果，并确定与结果相关的变量。方法：我们对出生在该国两个最大地区的 CH 儿童进行了病例对照研究。Leiter-R 和 TEVI-R 测试在家中对 69 名患有 CH 的儿童和 68 名匹配的对照受试者进行。获得了影响认知的其他变量。对 Leiter-R 和 TEVI-R 检验进行多变量逻辑回归分析，仅对案例使用一个模型，对案例和控制使用另一个模型。结果：在患有 CH 的儿童和对照组之间没有观察到 Leiter-R 和 TEVI-R 结果的差异。表现更好的孩子，无论他们是否有CH，都有更高的家庭收入和更多的资产。结论：这些结果表明，智利 NBS 计划策略导致儿童语言、注意力和记忆力发展正常。社会经济劣势代表了认知功能的重大损害。这些结果表明，智利的 NBS 计划策略导致儿童的语言、注意力和记忆力发展正常。社会经济劣势代表了认知功能的重大损害。这些结果表明，智利的 NBS 计划策略导致儿童的语言、注意力和记忆力发展正常。社会经济劣势代表了认知功能的重大损害。