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Evaluation of the Thermal Hazard of the Oxidation Reaction in the Synthesis of 3,4-Bis(4-nitrofurazan-3-yl)furoxan
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2022-04-19 , DOI: 10.1021/acs.oprd.1c00458 Yanlong Zhu 1, 2 , Li Ding 2 , Luping Xu 2 , Hai Chang 2 , Xiaofeng Wang 2 , Xiaoling Zhang 1
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2022-04-19 , DOI: 10.1021/acs.oprd.1c00458 Yanlong Zhu 1, 2 , Li Ding 2 , Luping Xu 2 , Hai Chang 2 , Xiaofeng Wang 2 , Xiaoling Zhang 1
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Safety evaluation of chemical reactions is very significant before industrial applications are conducted. A lot of thermal hazards are generated in the synthesis of 3,4-bis(4-nitrofurazan-3-yl)furoxan (DNTF) because of the strong exothermicity of the oxidation reaction, unstable hydrogen peroxide, and interactions between the materials. In this article, systematic parameters regarding the safe synthesis of DNTF were studied, including the preparation stage of reaction solution and the oxidation reaction step. A Calvet microcalorimeter and an RC1mx reaction calorimeter were employed for process safety research. Differential scanning calorimetry and adiabatic accelerating rate calorimetry were used to investigate the thermal stabilities of the materials and their thermal hazards. After screening of the thermal stabilities of the materials in the two stages, hazardous materials were identified, and their thermal safety parameters were obtained. Finally, two evaluation methods were applied to evaluate the hazard levels of the preparation process and the oxidation reaction process in the synthesis of DNTF on the basis of thermal safety parameters. This study provides critical safety technical guidance for the DNTF synthesis process and safety design.
中文翻译：
3,4-双(4-nitrofurazan-3-yl)furoxan合成中氧化反应的热危害评价
在进行工业应用之前，化学反应的安全性评估非常重要。3,4-双(4-nitrofurazan-3-yl)furoxan (DNTF)的合成过程中由于氧化反应放热性强、过氧化氢不稳定以及材料间的相互作用等原因，会产生大量的热危害。本文研究了安全合成DNTF的系统参数，包括反应溶液的制备阶段和氧化反应步骤。Calvet 微量热计和 RC1mx 反应量热计用于工艺安全研究。采用差示扫描量热法和绝热加速速率量热法研究材料的热稳定性及其热危害。对两阶段材料的热稳定性进行筛选后，对有害物质进行鉴定，得到其热安全参数。最后，基于热安全参数，采用两种评价方法对DNTF合成过程中的制备过程和氧化反应过程的危害等级进行了评价。该研究为DNTF合成过程和安全设计提供了关键的安全技术指导。
更新日期：2022-04-19
中文翻译：
3,4-双(4-nitrofurazan-3-yl)furoxan合成中氧化反应的热危害评价
在进行工业应用之前，化学反应的安全性评估非常重要。3,4-双(4-nitrofurazan-3-yl)furoxan (DNTF)的合成过程中由于氧化反应放热性强、过氧化氢不稳定以及材料间的相互作用等原因，会产生大量的热危害。本文研究了安全合成DNTF的系统参数，包括反应溶液的制备阶段和氧化反应步骤。Calvet 微量热计和 RC1mx 反应量热计用于工艺安全研究。采用差示扫描量热法和绝热加速速率量热法研究材料的热稳定性及其热危害。对两阶段材料的热稳定性进行筛选后，对有害物质进行鉴定，得到其热安全参数。最后，基于热安全参数，采用两种评价方法对DNTF合成过程中的制备过程和氧化反应过程的危害等级进行了评价。该研究为DNTF合成过程和安全设计提供了关键的安全技术指导。
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