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A Nanopore Based Molnupiravir Sensor
ACS Sensors ( IF 8.2 ) Pub Date : 2022-04-15 , DOI: 10.1021/acssensors.2c00447 Wendong Jia 1, 2 , Chengzhen Hu 1, 2 , Yuqin Wang 1, 2 , Panke Zhang 1 , Hong-Yuan Chen 1 , Shuo Huang 1, 2
ACS Sensors ( IF 8.2 ) Pub Date : 2022-04-15 , DOI: 10.1021/acssensors.2c00447 Wendong Jia 1, 2 , Chengzhen Hu 1, 2 , Yuqin Wang 1, 2 , Panke Zhang 1 , Hong-Yuan Chen 1 , Shuo Huang 1, 2
Affiliation
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Nucleoside analogues are reagents that resemble the structure of natural nucleosides and are widely applied in antiviral and anticancer therapy. Molnupiravir, a recently reported nucleoside analogue drug, has shown its inhibitory effect against SARS-CoV-2. Rapid tracing of molnupiravir and its metabolites is important in the evaluation of its pharmacology effect, but direct sensing of molnupiravir as a single molecule has not been reported to date. Here, we demonstrate a nanopore-based sensor with which direct sensing of molnupiravir and its two major metabolites β-d-N4-hydroxycytidine and its triphosphate can be achieved simultaneously. In conjunction with a custom machine learning algorithm, an accuracy of 92% was achieved. This sensing strategy may be useful in the current pandemic and is in principle suitable for other nucleoside analogue drugs.
中文翻译：
基于纳米孔的莫努匹韦传感器
核苷类似物是类似于天然核苷结构的试剂，广泛应用于抗病毒和抗癌治疗。最近报道的核苷类似物药物莫努匹拉韦已显示出对SARS-CoV-2的抑制作用。莫努匹韦及其代谢物的快速追踪对于评估其药理作用很重要，但迄今为止尚未报道将莫努匹韦作为单分子直接传感。在这里，我们展示了一种基于纳米孔的传感器，它可以直接感应莫努匹韦及其两种主要代谢物 β- d - N4-羟基胞苷及其三磷酸可以同时实现。结合自定义机器学习算法，实现了 92% 的准确率。这种传感策略可能在当前的大流行中有用，并且原则上适用于其他核苷类似物药物。
更新日期：2022-04-15
中文翻译：
基于纳米孔的莫努匹韦传感器
核苷类似物是类似于天然核苷结构的试剂，广泛应用于抗病毒和抗癌治疗。最近报道的核苷类似物药物莫努匹拉韦已显示出对SARS-CoV-2的抑制作用。莫努匹韦及其代谢物的快速追踪对于评估其药理作用很重要，但迄今为止尚未报道将莫努匹韦作为单分子直接传感。在这里，我们展示了一种基于纳米孔的传感器，它可以直接感应莫努匹韦及其两种主要代谢物 β- d - N4-羟基胞苷及其三磷酸可以同时实现。结合自定义机器学习算法，实现了 92% 的准确率。这种传感策略可能在当前的大流行中有用，并且原则上适用于其他核苷类似物药物。
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