Synthesis, Renal Clearance, and Photothermal Therapy Based on the Self-Assembly of a Nanomedicine Consisting of Quaterrylene Bisimide and Glycocluster Conjugates,ACS Macro Letters

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Synthesis, Renal Clearance, and Photothermal Therapy Based on the Self-Assembly of a Nanomedicine Consisting of Quaterrylene Bisimide and Glycocluster Conjugates
ACS Macro Letters ( IF 5.1 ) Pub Date : 2022-04-18 , DOI: 10.1021/acsmacrolett.2c00093
Ya-Li Luo _{1,

2} , Hui-Yan Zhang _{1,

2} , Guo-Kai Li _{1,

2} , Ying-Ying Zhao _{1,

2} , Yan Yang _{2,

3} , Rui-Xue Rong _{2,

3} , Xiao-Liu Li _{1,

2} , Ke-Rang Wang _{1,

2}

Affiliation

Renal-clearable nanomedicines are considered the next generation of nanomedicines, and show potential application for future clinical translations. However, it is important to determine whether self-assembly can form large aggregates that accrue in tumors and then tailor the size of these assemblies to be excreted renally. In this paper, a renal-clearable nanomedicine based on quanterrylene bisimide-mannose conjugates (QDI-Man) was developed. QDI-Man showed a high renal clearance efficiency of 80.31 ± 2.85% in mice. We confirmed that the self-assembly of QDI-Man exhibited a dynamic adjustment process through the renal filtration thresholds, that is, “aggregation → self-regulating the aggregate size through the renal filtration thresholds → reaggregating into aggregates”. Benefiting from the modification of mannose-based glycoclusters, QDI-Man showed selective photothermal therapy because of the mannose receptors overexpressed in breast cancer cells, and showed good photothermal therapy in mice. This paper developed a dynamic adjustment theory for effective renal clearance based on organic self-assembly.

中文翻译：

基于由四亚甲基双酰亚胺和糖簇缀合物组成的纳米药物的自组装合成、肾脏清除和光热治疗

肾脏可清除的纳米药物被认为是下一代纳米药物，并显示出未来临床转化的潜在应用。然而，重要的是确定自组装是否可以形成在肿瘤中累积的大聚集体，然后调整这些组装的大小以通过肾脏排泄。在本文中，开发了一种基于二亚胺-甘露糖偶联物（QDI-Man）的肾脏可清除纳米药物。QDI-Man在小鼠中显示出 80.31 ± 2.85% 的高肾脏清除效率。我们确认了QDI-Man的自组装通过肾滤过阈值表现出动态调节过程，即“聚集→通过肾滤过阈值自我调节聚集体大小→重新聚集成聚集体”。受益于基于甘露糖的糖簇的修饰，QDI-Man由于在乳腺癌细胞中过表达的甘露糖受体而显示出选择性光热疗法，并且在小鼠中显示出良好的光热疗法。本文提出了一种基于有机自组装的有效肾脏清除动态调节理论。

更新日期：2022-04-18

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