Starting from studying a melanoma patient with heterogenous response, In article 2100098, Lujun Shen, Ying Wu, and co-workers identified inducible regulatory T cells (iTregs) as a key predictor of treatment response of PD-1 inhibitor based immunotherapy in melanoma. Further analysis of multi-omics data of this special patient and public datasets uncover the molecular features and potential therapeutic targets of iTregs.

中文翻译：

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诱导型调节性 T 细胞预测 PD-1 阻断疗法在黑色素瘤中的疗效（Adv. Therap. 4/2022）

从研究具有异源反应的黑色素瘤患者开始，在文章 2100098 中，Lujun Shen、Ying Wu 及其同事将诱导型调节性 T 细胞 (iTregs) 确定为基于 PD-1 抑制剂的免疫治疗在黑色素瘤中治疗反应的关键预测因子。对这一特殊患者和公共数据集的多组学数据的进一步分析揭示了 iTregs 的分子特征和潜在治疗靶点。