Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in the world. The emerging field of cardio-oncology has revealed that these seemingly disparate disease processes are intertwined, owing to the cardiovascular sequelae of anticancer therapies, shared risk factors that predispose individuals to both cardiovascular disease and cancer, as well the possible potentiation of cancer growth by cardiac dysfunction. As a result, interest has increased in understanding the fundamental biological mechanisms that are central to the relationship between cardiovascular disease and cancer. Metabolism, appropriate regulation of energy, energy substrate utilization, and macromolecular synthesis and breakdown are fundamental processes for cellular and organismal survival. In this Review, we explore the emerging data identifying metabolic dysregulation as an important theme in cardio-oncology. We discuss the growing recognition of metabolic reprogramming in cardiovascular disease and cancer and view the novel area of cardio-oncology through the lens of metabolism.

心血管疾病和癌症是世界上发病率和死亡率的两大主要原因。新兴的心脏肿瘤学领域表明，由于抗癌治疗的心血管后遗症、使个体易患心血管疾病和癌症的共同风险因素，以及心脏疾病可能促进癌症生长，这些看似完全不同的疾病过程相互交织在一起。功能障碍。因此，人们越来越有兴趣了解对心血管疾病和癌症之间的关系至关重要的基本生物学机制。新陈代谢、适当的能量调节、能量底物利用以及大分子合成和分解是细胞和有机体生存的基本过程。在这篇评论中，我们探索将代谢失调确定为心脏肿瘤学重要主题的新兴数据。我们讨论了人们对心血管疾病和癌症中代谢重编程的日益认识，并通过代谢的视角来看待心脏肿瘤学的新领域。