Changes in regional oxygen saturation of the kidney and brain of infants during hospitalization,Journal of Clinical Monitoring and Computing

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Changes in regional oxygen saturation of the kidney and brain of infants during hospitalization
Journal of Clinical Monitoring and Computing ( IF 2.0 ) Pub Date : 2022-04-20 , DOI: 10.1007/s10877-022-00836-y
Daisuke Yoshida ₁ , Tomoyuki Shimokaze ₁ , Atsushi Kondo ₁ , Katsuaki Toyoshima ₁ , Tomoko Saito ₁

Affiliation

Background

In pre-term infants, the postnatal changes in the regional oxygen saturation (rSO₂) of the brain and kidney are unclear.

Methods

We performed a prospective observational study. We measured the cerebral/renal rSO₂ ratio and recorded the associated clinical features of infants born at 23 to 41 weeks of gestation weekly from the early postnatal period to discharge.

Results

The median cerebral/renal rSO₂ ratios (interquartile ranges) between birth and the expected date of birth were 1.13 (1.06–1.26) at 23–24 weeks (n = 7), 1.18 (1.10–1.32) at 25–26 weeks (n = 11), 1.24 (1.11–1.37) at 27–28 weeks (n = 9), 1.12 (1.05–1.19) at 29–30 weeks (n = 4), 1.11 (1.03–1.15) at 31–32 weeks (n = 5), 1.02 (0.98–1.06) at 33–34 weeks (n = 9), 0.98 (0.94–1.06) at 35–36 weeks (n = 19), and 0.95 (0.86–0.99) at 37–41 weeks of gestation (n = 22). The median cerebral/renal rSO₂ ratio did not significantly change after birth, but with increasing gestational age, the cerebral/renal rSO₂ ratio at the expected date of birth decreased (r = − 0.74, p < 0.001). Nephrotoxic drugs did not affect cerebral/renal rSO₂ at the expected date of birth, after adjustment for clinical factors.

Conclusions

Unlike in most infants born after the late pre-term period, the renal rSO₂ remained lower than the cerebral rSO₂ on the expected date of birth in infants born very pre-term.

中文翻译：

婴幼儿住院期间肾脑局部氧饱和度变化

背景

在早产儿中，大脑和肾脏的局部氧饱和度 (rSO _{2 ) 的产后变化尚不清楚。}

方法

我们进行了一项前瞻性观察研究。我们测量了脑/肾 rSO ₂比率，并记录了从产后早期到出院期间每周妊娠 23 至 41 周出生婴儿的相关临床特征。

结果

出生和预产期之间的脑/肾 rSO 2 比率中位数（四分位数间距）在 23-24 周时为 1.13 (1.06-1.26) (n = 7)，在 25-26 周时为 1.18 (1.10-1.32 ) _（ n = 11)，27-28 周时为 1.24 (1.11-1.37) (n = 9)，29-30 周时为 1.12 (1.05-1.19) (n = 4)，31-32 周时为 1.11 (1.03-1.15) (n = 5)，33-34 周时为 1.02 (0.98-1.06) (n = 9)，35-36 周时为 0.98 (0.94-1.06) (n = 19)，37-30 周时为 0.95 (0.86-0.99)妊娠 41 周 (n = 22)。大脑/肾脏 rSO ₂比率的中位数在出生后没有显着变化，但随着胎龄的增加，预产期的大脑/肾脏 rSO _{2比率下降（r = − 0.74，}p < 0.001）。肾毒性药物不影响脑/肾 rSO ₂在针对临床因素调整后的预产期。