Chronic skin wounds impose immense suffers and economic burdens. Current research mainly focuses on acute wound management which exhibits less effective in chronic wound healing. Growth differentiation factor 11 (GDF11) has profound effects on several important physiological processes related to chronic wound healing, such as inflammation, cell proliferation, migration, angiogenesis, and neurogenesis. This review summarizes recent advances in biology of chronic wounds and the potential role of GDF11 on wound healing with its regenerative effects, as well as the potential delivery methods of GDF11. The challenges and future perspectives of GDF11-based therapy for chronic wound care are also discussed.

The Translational Potential of this Article: This review summarized the significance of GDF11 in the modulation of inflammation, vascularization, cell proliferation, and remodeling, which are important physiological processes of chronic wound healing. The potential delivery methods of GDF11 in the management of chronic wound healing is also summarized. This review may provide potential therapeutic approaches based on GDF11 for chronic wound healing.

慢性皮肤伤口带来巨大的痛苦和经济负担。目前的研究主要集中在急性伤口管理上，它对慢性伤口愈合的效果较差。生长分化因子 11 (GDF11) 对与慢性伤口愈合相关的几个重要生理过程具有深远影响，例如炎症、细胞增殖、迁移、血管生成和神经发生。本综述总结了慢性伤口生物学的最新进展和 GDF11 在伤口愈合及其再生作用中的潜在作用，以及 GDF11 的潜在递送方法。还讨论了基于 GDF11 的慢性伤口护理疗法的挑战和未来前景。

本文的转化潜力：这篇综述总结了 GDF11 在调节炎症、血管化、细胞增殖和重塑中的意义，这些都是慢性伤口愈合的重要生理过程。还总结了 GDF11 在慢性伤口愈合管理中的潜在递送方法。本综述可能为基于 GDF11 的慢性伤口愈合提供潜在的治疗方法。